(data stored in ACNUC7421 zone)

SWISSPROT: A8KXA8_FRASN

ID   A8KXA8_FRASN            Unreviewed;       127 AA.
AC   A8KXA8;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   08-MAY-2019, entry version 69.
DE   RecName: Full=Ribonuclease VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE            Short=RNase VapC {ECO:0000256|HAMAP-Rule:MF_00265};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00265};
DE   AltName: Full=Toxin VapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN   Name=vapC {ECO:0000256|HAMAP-Rule:MF_00265};
GN   OrderedLocusNames=Franean1_0552 {ECO:0000313|EMBL:ABW10011.1};
OS   Frankia sp. (strain EAN1pec).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW10011.1, ECO:0000313|Proteomes:UP000001313};
RN   [1] {ECO:0000313|Proteomes:UP000001313}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EAN1pec {ECO:0000313|Proteomes:UP000001313};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N.,
RA   Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N.,
RA   Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L.,
RA   Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E.,
RA   Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z.,
RA   Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D.,
RA   Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) system. An
CC       RNase. {ECO:0000256|HAMAP-Rule:MF_00265}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00265, ECO:0000256|SAAS:SAAS00608033};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000256|HAMAP-Rule:MF_00265, ECO:0000256|SAAS:SAAS00541436}.
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DR   EMBL; CP000820; ABW10011.1; -; Genomic_DNA.
DR   RefSeq; WP_020458205.1; NC_009921.1.
DR   STRING; 298653.Franean1_0552; -.
DR   EnsemblBacteria; ABW10011; ABW10011; Franean1_0552.
DR   KEGG; fre:Franean1_0552; -.
DR   eggNOG; ENOG41061EZ; Bacteria.
DR   eggNOG; COG1487; LUCA.
DR   HOGENOM; HOG000121274; -.
DR   OMA; FDPLPID; -.
DR   OrthoDB; 1968541at2; -.
DR   BioCyc; FSP298653:G1G9X-546-MONOMER; -.
DR   Proteomes; UP000001313; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   HAMAP; MF_00265; VapC_Nob1; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR022907; VapC_family.
DR   Pfam; PF01850; PIN; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8KXA8.
DR   SWISS-2DPAGE; A8KXA8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001313};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00423921};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00541414};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00423897};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00423900};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001313};
KW   Toxin {ECO:0000256|HAMAP-Rule:MF_00265};
KW   Toxin-antitoxin system {ECO:0000256|HAMAP-Rule:MF_00265,
KW   ECO:0000256|SAAS:SAAS00986330}.
FT   DOMAIN       21    111       PINc. {ECO:0000259|Pfam:PF01850}.
FT   METAL         7      7       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00265}.
FT   METAL        93     93       Magnesium. {ECO:0000256|HAMAP-Rule:
FT                                MF_00265}.
SQ   SEQUENCE   127 AA;  13555 MW;  9C3C8E12EFA8763C CRC64;
     MNRGVLDTSV LVATDVTPIP GELAVSVISI AELQFGILVA KTPQARATRL ARLSTIQRRF
     DPLPIDDAVA DSYGRLAARV VEAGRQPRAR TMDLLIAATA HAHGASIYTR NAADLAGLED
     LLRIVTI
//

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