(data stored in ACNUC7421 zone)

SWISSPROT: PYRB_DESOH

ID   PYRB_DESOH              Reviewed;         311 AA.
AC   A8ZU12;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   11-DEC-2019, entry version 69.
DE   RecName: Full=Aspartate carbamoyltransferase {ECO:0000255|HAMAP-Rule:MF_00001};
DE            EC=2.1.3.2 {ECO:0000255|HAMAP-Rule:MF_00001};
DE   AltName: Full=Aspartate transcarbamylase {ECO:0000255|HAMAP-Rule:MF_00001};
DE            Short=ATCase {ECO:0000255|HAMAP-Rule:MF_00001};
GN   Name=pyrB {ECO:0000255|HAMAP-Rule:MF_00001}; OrderedLocusNames=Dole_0514;
OS   Desulfococcus oleovorans (strain DSM 6200 / Hxd3).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfobacterales;
OC   Desulfobacteraceae; Desulfococcus.
OX   NCBI_TaxID=96561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6200 / Hxd3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Wawrik B.,
RA   Richardson P.;
RT   "Complete sequence of Desulfococcus oleovorans Hxd3.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00001};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       (S)-dihydroorotate from bicarbonate: step 2/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00001}.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. ATCase family. {ECO:0000255|HAMAP-Rule:MF_00001}.
DR   EMBL; CP000859; ABW66324.1; -; Genomic_DNA.
DR   RefSeq; WP_012173943.1; NC_009943.1.
DR   SMR; A8ZU12; -.
DR   STRING; 96561.Dole_0514; -.
DR   PRIDE; A8ZU12; -.
DR   EnsemblBacteria; ABW66324; ABW66324; Dole_0514.
DR   KEGG; dol:Dole_0514; -.
DR   eggNOG; ENOG4105CXT; Bacteria.
DR   eggNOG; COG0540; LUCA.
DR   HOGENOM; HOG000022685; -.
DR   KO; K00609; -.
DR   OMA; FPTEREY; -.
DR   OrthoDB; 1844275at2; -.
DR   BioCyc; DOLE96561:G1GAC-530-MONOMER; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000008561; Chromosome.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; -; 2.
DR   HAMAP; MF_00001; Asp_carb_tr; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   PANTHER; PTHR11405:SF16; PTHR11405:SF16; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   SUPFAM; SSF53671; SSF53671; 1.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; A8ZU12.
DR   SWISS-2DPAGE; A8ZU12.
KW   Pyrimidine biosynthesis; Reference proteome; Transferase.
FT   CHAIN           1..311
FT                   /note="Aspartate carbamoyltransferase"
FT                   /id="PRO_1000088759"
SQ   SEQUENCE   311 AA;  33580 MW;  F90A9F7721D2A090 CRC64;
     MGLSTRDILD MGSLSRKDIS LVLDTARSMK EISLRPVKKV PTLRGKTVVS FFYEPSTRTK
     VSFDVAAKRL SADSISLSVA TSSMTKGETL LDTVKNLERM SPDVVVIRHS SAGVPHMLAR
     HVSVPVINAG DGMHAHPSQA LLDMMTVQEK KGRIEGLRLA IIGDIARSRV ARSNVEGFLK
     MGASVVLAAP PTMIPVGVET FGADVTHNVD EAIAGADVIM MLRIQKERAA AFLFSTVREY
     ARTYGLTANR LKNAKKDVLI MHPGPVNRGV EIAPEVADGP YSVILDQVEN GVAVRMALFY
     LVMGGQRDAG D
//

If you have problems or comments...

PBIL Back to PBIL home page