(data stored in ACNUC1104 zone)

SWISSPROT: B1K1W7_BURCC

ID   B1K1W7_BURCC            Unreviewed;       512 AA.
AC   B1K1W7;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   SubName: Full=Drug resistance transporter, EmrB/QacA subfamily {ECO:0000313|EMBL:ACA92546.1};
GN   OrderedLocusNames=Bcenmc03_3392 {ECO:0000313|EMBL:ACA92546.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92546.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; CP000959; ACA92546.1; -; Genomic_DNA.
DR   EnsemblBacteria; ACA92546; ACA92546; Bcenmc03_3392.
DR   KEGG; bcm:Bcenmc03_3392; -.
DR   HOGENOM; HOG000112191; -.
DR   KO; K03446; -.
DR   OMA; QDEITWV; -.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K1W7.
DR   SWISS-2DPAGE; B1K1W7.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     21     45       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     57     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     87    109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    115    134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    173    194       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    237    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    309    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    369    390       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    478    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       21    500       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   512 AA;  54592 MW;  6C90689E7BAE7436 CRC64;
     MNPAAADADT PASPALNRPM LTLSIMLATL IQTLDSTIAN VALPHMQGTL SASQDEITWV
     LTSYIVAAAI ATPLTGWLSD RLSVKRLLIV SIAGFTVASA LCGLSETLVQ IVGARLLQGV
     FGAALVPLSQ SILLDINPRE KQGQAMAIWG MGVMVGPILG PTLGGWLTDS YNWRWVFFIN
     VPIGAFALAG VMTFLPARAP RPHVKFDAFG FATLALAIGA FQAMLDRGEQ LDWFGSYEIR
     IEALVAALSF AFFLAHTATV GKASFFKSEL LRDPNFATGT LFIFVVGAVL YATRALLPPM
     LQNLMGYPVA TTGLVTAPSG AGTMIAMLFV GRLLKYVDAR MLLLAGLAIS ALALWQMMQY
     TVVLSEADIV WPGVIQGFGL GLVFVPLSAL SFSTLPPELR ADGTATYSLM RNIGSSIGIS
     IVQTLMTRNT QVAHADLATH VTPFNPAVQA LAGSRVDLAL LDRTINQQAA MIAYLNDFKL
     MFVATLLMIP LLLLIRPPQK AASVDVAHAA MD
//

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