(data stored in ACNUC1104 zone)

SWISSPROT: B1K1Y2_BURCC

ID   B1K1Y2_BURCC            Unreviewed;       310 AA.
AC   B1K1Y2;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   RecName: Full=Proline iminopeptidase {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
DE            Short=PIP {ECO:0000256|PIRNR:PIRNR006431};
DE            EC=3.4.11.5 {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
DE   AltName: Full=Prolyl aminopeptidase {ECO:0000256|PIRNR:PIRNR006431};
GN   OrderedLocusNames=Bcenmc03_3408 {ECO:0000313|EMBL:ACA92561.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92561.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of N-terminal proline from a peptide.;
CC         EC=3.4.11.5; Evidence={ECO:0000256|PIRNR:PIRNR006431,
CC         ECO:0000256|RuleBase:RU003421};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006431}.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
CC       {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421}.
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DR   EMBL; CP000959; ACA92561.1; -; Genomic_DNA.
DR   RefSeq; WP_012338358.1; NC_010515.1.
DR   ESTHER; burch-a0azm5; Proline_iminopeptidase.
DR   MEROPS; S33.001; -.
DR   EnsemblBacteria; ACA92561; ACA92561; Bcenmc03_3408.
DR   KEGG; bcm:Bcenmc03_3408; -.
DR   HOGENOM; HOG000171480; -.
DR   KO; K01259; -.
DR   OMA; PDKWERF; -.
DR   BioCyc; BCEN406425:G1GBC-3618-MONOMER; -.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR002410; Peptidase_S33.
DR   InterPro; IPR005944; Pro_iminopeptidase.
DR   PANTHER; PTHR43722; PTHR43722; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF006431; Pept_S33; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   PRINTS; PR00793; PROAMNOPTASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   TIGRFAMs; TIGR01249; pro_imino_pep_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K1Y2.
DR   SWISS-2DPAGE; B1K1Y2.
KW   Aminopeptidase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421, ECO:0000313|EMBL:ACA92561.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR006431};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421, ECO:0000313|EMBL:ACA92561.1};
KW   Protease {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421}.
FT   DOMAIN       35    291       AB hydrolase-1. {ECO:0000259|Pfam:
FT                                PF00561}.
FT   ACT_SITE    107    107       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006431-1}.
FT   ACT_SITE    262    262       {ECO:0000256|PIRSR:PIRSR006431-1}.
FT   ACT_SITE    290    290       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006431-1}.
SQ   SEQUENCE   310 AA;  34567 MW;  2621055AAA046039 CRC64;
     MYPPIEPYAH GHLDTGDGHR IYWERCGNPA GKPAVFLHGG PGAGCGPDHR RLFDPERYDI
     LLFDQRGCGR STPHASLENN TTWDLVADIE RLREMVGAEQ WLVFGGSWGS ALAIAYAETH
     PERVSALIVR GIFTMRRVEL LWYYQEGASW LFPDHWEDFL APIPEAERGD LMAAYHRRLT
     GDDEAAKLEA ARAWSIWEGR TITLLPDPAL AAHFADGHYA LAFARIENHY FVNKGFVEEG
     QLLRDAHRLA GIPGVIVQGR YDIATPARTA WELSKAWPEA TFEIVPGAGH AYNEPGILEA
     LVAATDRFAA
//

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