(data stored in ACNUC1104 zone)

SWISSPROT: B1K3N1_BURCC

ID   B1K3N1_BURCC            Unreviewed;       905 AA.
AC   B1K3N1;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   RecName: Full=Aconitate hydratase {ECO:0000256|RuleBase:RU361275};
DE            Short=Aconitase {ECO:0000256|RuleBase:RU361275};
DE            EC=4.2.1.3 {ECO:0000256|RuleBase:RU361275};
GN   OrderedLocusNames=Bcenmc03_3600 {ECO:0000313|EMBL:ACA92752.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92752.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the isomerization of citrate to isocitrate via
CC       cis-aconitate. {ECO:0000256|RuleBase:RU361275}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=citrate = isocitrate; Xref=Rhea:RHEA:10336,
CC         ChEBI:CHEBI:16087, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU361275};
CC   -!- COFACTOR:
CC       Note=Binds 1 [4Fe-4S] cluster per subunit.
CC       {ECO:0000256|RuleBase:RU361275};
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC       {ECO:0000256|RuleBase:RU361275}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000959; ACA92752.1; -; Genomic_DNA.
DR   RefSeq; WP_011548110.1; NC_010515.1.
DR   EnsemblBacteria; ACA92752; ACA92752; Bcenmc03_3600.
DR   KEGG; bcm:Bcenmc03_3600; -.
DR   HOGENOM; HOG000025703; -.
DR   KO; K01681; -.
DR   OMA; RDFTQEG; -.
DR   BioCyc; BCEN406425:G1GBC-3822-MONOMER; -.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.19.10; -; 1.
DR   Gene3D; 3.30.499.10; -; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   PANTHER; PTHR11670; PTHR11670; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; SSF53732; 1.
DR   TIGRFAMs; TIGR01341; aconitase_1; 1.
DR   PROSITE; PS00450; ACONITASE_1; 1.
DR   PROSITE; PS01244; ACONITASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K3N1.
DR   SWISS-2DPAGE; B1K3N1.
KW   4Fe-4S {ECO:0000256|RuleBase:RU361275};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   Iron {ECO:0000256|RuleBase:RU361275};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU361275};
KW   Lyase {ECO:0000256|RuleBase:RU361275};
KW   Metal-binding {ECO:0000256|RuleBase:RU361275}.
FT   DOMAIN       69    566       Aconitase. {ECO:0000259|Pfam:PF00330}.
FT   DOMAIN      697    829       Aconitase_C. {ECO:0000259|Pfam:PF00694}.
SQ   SEQUENCE   905 AA;  98605 MW;  74DEADECAE2B7208 CRC64;
     MAHNLHKTLK EFDSGSGKGK FYSLPQLGKE LKTKIERLPV SIRIVLESVL RNYDGKKITE
     EHIEQLANWK PTAKRVDEIP FVVSRVVLQD FTGVPLLADI AAMRGVAERT GKNPKKIEPL
     VPVDLVVDHS VQIDYFRQKD ALDLNMKLEF QRNNERYQFM KWGMQAFDTF KVVPPGVGIV
     HQVNLEYLAR GVHKKTDGGD TVYYPDTLVG TDSHTTMING IGVVGWGVGG IEAEAGMLGQ
     PVYFLTPDVV GVELKGKLRE GVTATDLVLT ITEMLRKEKV VGKFVEFFGE GTRSLSLPDR
     ATIGNMAPEY GATMGFFPVD EKTIDYFEGT GRTKAEIAAF ENYFKAQNLF GIPKAGDIDY
     TKTVTLDLAT VAPSLAGPKR PQDRIEIGHV KSTFTDLFSK PVAENGFAKK AEDLNTQYTT
     SNGVDVKNGD VLIAAITSCT NTSNPSVLLA AGLLAKKAVE AGLTVDPKIK TSLAPGSRIV
     TEYLTKTGLL PYLSKLGFEV AAYGCTTCIG NAGDLTPELN EAITKNDIVA AAVLSGNRNF
     EARIHPNIRA NFLASPPLVV AYAIAGNITR DLMTEPVGKG KGGRDIYLGD IWPTSDEIHA
     LLKFALDPKK FEDNYSKLTK KGDLWSKIEG ESGEVYDWPK STYIAEPPFF GNDFSMEPAA
     SIPTVKGARA LGIFGDSVTT DHISPAGSIK EDSPAGKWLK ENGVQKADFN SYGSRRGNHD
     VMMRGTFANV RIKNLMIPPK ADGTRVEGGL TIHQPSGEQQ SIYDAAMQYV AAGTPTVVFA
     GEEYGTGSSR DWAAKGTQLL GVKAVIARSF ERIHRSNLVG MGVLPLQFKG ADSVQSLGIT
     GEETYDIEGL GDDFKPQQDV TLVIHRKNGE TQRVPVLLRI DTPIEVDYYK HGGILPFVLR
     SLLAA
//

If you have problems or comments...

PBIL Back to PBIL home page