(data stored in ACNUC1104 zone)

SWISSPROT: B1K4W7_BURCC

ID   B1K4W7_BURCC            Unreviewed;       527 AA.
AC   B1K4W7;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:ACA92891.1};
GN   OrderedLocusNames=Bcenmc03_3739 {ECO:0000313|EMBL:ACA92891.1};
OS   Burkholderia cenocepacia (strain MC0-3).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=406425 {ECO:0000313|EMBL:ACA92891.1, ECO:0000313|Proteomes:UP000002169};
RN   [1] {ECO:0000313|Proteomes:UP000002169}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC0-3 {ECO:0000313|Proteomes:UP000002169};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-
RT   3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC       (CPA1) transporter (TC 2.A.36) family.
CC       {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; CP000959; ACA92891.1; -; Genomic_DNA.
DR   RefSeq; WP_012338511.1; NC_010515.1.
DR   EnsemblBacteria; ACA92891; ACA92891; Bcenmc03_3739.
DR   KEGG; bcm:Bcenmc03_3739; -.
DR   HOGENOM; HOG000263348; -.
DR   KO; K03316; -.
DR   OMA; RRIDDEM; -.
DR   BioCyc; BCEN406425:G1GBC-3970-MONOMER; -.
DR   Proteomes; UP000002169; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1K4W7.
DR   SWISS-2DPAGE; B1K4W7.
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|RuleBase:RU366002};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002169};
KW   Ion transport {ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM      6     24       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     31     51       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     57     76       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     83    105       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    111    136       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    157    176       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    188    207       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    214    230       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    266    288       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    308    327       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    348    367       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    379    402       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   DOMAIN       10    403       Na_H_Exchanger. {ECO:0000259|Pfam:
FT                                PF00999}.
SQ   SEQUENCE   527 AA;  57098 MW;  E54C3711B9E29BC0 CRC64;
     MSPVSAFKLV LLSFLAIVAL ECIAKRLRLP PAAALLIGGI GIAFIPGLPP INLDPELVLL
     VFLPPLLMDG AYFSVWEEFK RNVGGILMLA IGAVVFTTFA VGFAVHWVVP ALPWAACFAL
     GAIVSPPDAV AAKAVLERVA LPRRLMVLLE GESLLNDAAG LVLFRFAVAA ALTGAFSLEH
     AVVRFAELGL GGVVVGFVVG KLVVWFLKLL DDDYLVITVA VIAGWIAYIA GEMVEVSGVI
     STVTAGMIIG WHQHEVFSAA VRTRGTAFWQ VIVFLLEAMV FVLIGLSLRG AIHRLGGFEQ
     VLGTMVPPVL AVLAAVVLSR FVWIYAVEAL KWPVRGLARR GEAPDWKAAT IMSWAGMRGV
     VTLAIALSLP EALPGRDVIL VASFAVILVT VLLQGTTIGP LIRLLRLPQR EERAAHHLTE
     PQTWAYVEAA QLAAIQPLVR DENGVVIHPR LLEQYTYRAE LTERAKNEPA YPAEVRMAHY
     DVVLAAIRAG RAELLRLHRS GRIHDEMLHA LERDLDLQEV SAQHARG
//

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