(data stored in ACNUC7421 zone)

SWISSPROT: RIHC_ECODH

ID   RIHC_ECODH              Reviewed;         304 AA.
AC   B1XBF5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 53.
DE   RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE   AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN   Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432};
GN   OrderedLocusNames=ECDH10B_0031;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides
CC       with a broad-substrate specificity. {ECO:0000255|HAMAP-
CC       Rule:MF_01432}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01432}.
DR   EMBL; CP000948; ACB01235.1; -; Genomic_DNA.
DR   RefSeq; WP_001239142.1; NC_010473.1.
DR   ProteinModelPortal; B1XBF5; -.
DR   SMR; B1XBF5; -.
DR   EnsemblBacteria; ACB01235; ACB01235; ECDH10B_0031.
DR   KEGG; ecd:ECDH10B_0031; -.
DR   eggNOG; ENOG4105DU0; Bacteria.
DR   eggNOG; COG1957; LUCA.
DR   HOGENOM; HOG000218839; -.
DR   KO; K12700; -.
DR   OMA; TPVAEWN; -.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR023186; Inosine/uridine_hydrolase.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XBF5.
DR   SWISS-2DPAGE; B1XBF5.
KW   Glycosidase; Hydrolase.
FT   CHAIN         1    304       Non-specific ribonucleoside hydrolase
FT                                RihC.
FT                                /FTId=PRO_1000145812.
FT   ACT_SITE    233    233       {ECO:0000255|HAMAP-Rule:MF_01432}.
SQ   SEQUENCE   304 AA;  32561 MW;  0E98D78DF5C6F70F CRC64;
     MRLPIFLDTD PGIDDAVAIA AAIFAPELDL QLMTTVAGNV SVEKTTRNAL QLLHFWNAEI
     PLAQGAAVPL VRAPRDAASV HGESGMAGYD FVEHNRKPLG IPAFLAIRDA LMRAPEPVTL
     VAIGPLTNIA LLLSQCPECK PYIRRLVIMG GSAGRGNCTP NAEFNIAADP EAAACVFRSG
     IEIVMCGLDV TNQAILTPDY LSTLPQLNRT GKMLHALFSH YRSGSMQSGL RMHDLCAIAW
     LVRPDLFTLK PCFVAVETQG EFTSGTTVVD IDGCLGKPAN VQVALDLDVK GFQQWVAEVL
     ALAS
//

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