(data stored in ACNUC7421 zone)

SWISSPROT: SECM_ECODH

ID   SECM_ECODH              Reviewed;         170 AA.
AC   B1XC74;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 44.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN   OrderedLocusNames=ECDH10B_0079;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of
CC       the secM secA operon. Translational pausing at a specific Pro
CC       residue 5 residues before the end of the protein may allow
CC       disruption of a mRNA repressor helix that normally suppresses secA
CC       translation initiation. {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}.
CC       Note=The active form is cytosolic, while the periplasmic form is
CC       rapidly degraded, mainly by the tail-specific protease.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
DR   EMBL; CP000948; ACB01278.1; -; Genomic_DNA.
DR   RefSeq; WP_000014321.1; NC_010473.1.
DR   ProteinModelPortal; B1XC74; -.
DR   SMR; B1XC74; -.
DR   EnsemblBacteria; ACB01278; ACB01278; ECDH10B_0079.
DR   KEGG; ecd:ECDH10B_0079; -.
DR   eggNOG; ENOG4108SR7; Bacteria.
DR   eggNOG; ENOG4111GJA; LUCA.
DR   HOGENOM; HOG000267813; -.
DR   KO; K13301; -.
DR   OMA; SAWISQV; -.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
DR   ProDom; PD089227; SecM; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XC74.
DR   SWISS-2DPAGE; B1XC74.
KW   Cytoplasm; Periplasm; Signal.
FT   SIGNAL        1     37       {ECO:0000255|HAMAP-Rule:MF_01332}.
FT   CHAIN        38    170       Secretion monitor.
FT                                /FTId=PRO_1000142337.
SQ   SEQUENCE   170 AA;  18880 MW;  5F5B3001056CAD22 CRC64;
     MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
     QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
     TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISQAQ GIRAGPQRLT
//

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