(data stored in ACNUC7421 zone)

SWISSPROT: YACG_ECODH

ID   YACG_ECODH              Reviewed;          65 AA.
AC   B1XC77;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 58.
DE   RecName: Full=DNA gyrase inhibitor YacG {ECO:0000255|HAMAP-Rule:MF_00649};
GN   Name=yacG {ECO:0000255|HAMAP-Rule:MF_00649};
GN   OrderedLocusNames=ECDH10B_0082;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC       preventing its interaction with DNA. Acts by binding directly to
CC       the C-terminal domain of GyrB, which probably disrupts DNA binding
CC       by the gyrase. {ECO:0000255|HAMAP-Rule:MF_00649}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00649};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00649};
CC   -!- SUBUNIT: Interacts with GyrB. {ECO:0000255|HAMAP-Rule:MF_00649}.
CC   -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00649}.
DR   EMBL; CP000948; ACB01281.1; -; Genomic_DNA.
DR   RefSeq; WP_000005042.1; NC_010473.1.
DR   ProteinModelPortal; B1XC77; -.
DR   SMR; B1XC77; -.
DR   EnsemblBacteria; ACB01281; ACB01281; ECDH10B_0082.
DR   KEGG; ecd:ECDH10B_0082; -.
DR   eggNOG; ENOG41067SF; Bacteria.
DR   eggNOG; COG3024; LUCA.
DR   HOGENOM; HOG000255917; -.
DR   KO; K09862; -.
DR   OMA; WAAEEHK; -.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR   InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF03884; YacG; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XC77.
DR   SWISS-2DPAGE; B1XC77.
KW   Metal-binding; Zinc.
FT   CHAIN         1     65       DNA gyrase inhibitor YacG.
FT                                /FTId=PRO_1000130960.
FT   METAL         9      9       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
FT   METAL        12     12       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
FT   METAL        28     28       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
FT   METAL        32     32       Zinc. {ECO:0000255|HAMAP-Rule:MF_00649}.
SQ   SEQUENCE   65 AA;  7306 MW;  F2747B62AFE6479D CRC64;
     MSETITVNCP TCGKTVVWGE ISPFRPFCSK RCQLIDLGEW AAEEKRIPSS GDLSESDDWS
     EEPKQ
//

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