(data stored in ACNUC7421 zone)

SWISSPROT: CRL_ECODH

ID   CRL_ECODH               Reviewed;         133 AA.
AC   B1XDY3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 56.
DE   RecName: Full=Sigma factor-binding protein Crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   Name=crl {ECO:0000255|HAMAP-Rule:MF_01178};
GN   OrderedLocusNames=ECDH10B_0222;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Binds to the sigma-S subunit of RNA polymerase,
CC       activating expression of sigma-S-regulated genes. Stimulates RNA
CC       polymerase holoenzyme formation and may bind to several other
CC       sigma factors, such as sigma-70 and sigma-32. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01178}.
CC   -!- SIMILARITY: Belongs to the Crl family. {ECO:0000255|HAMAP-
CC       Rule:MF_01178}.
DR   EMBL; CP000948; ACB01407.1; -; Genomic_DNA.
DR   RefSeq; WP_000174689.1; NC_010473.1.
DR   ProteinModelPortal; B1XDY3; -.
DR   SMR; B1XDY3; -.
DR   EnsemblBacteria; ACB01407; ACB01407; ECDH10B_0222.
DR   KEGG; ecd:ECDH10B_0222; -.
DR   eggNOG; ENOG4108UVK; Bacteria.
DR   eggNOG; ENOG4111IQF; LUCA.
DR   HOGENOM; HOG000282284; -.
DR   KO; K11926; -.
DR   OMA; FWGWWLE; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   HAMAP; MF_01178; Crl; 1.
DR   InterPro; IPR009986; Tscrpt_reg_Crl.
DR   Pfam; PF07417; Crl; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XDY3.
DR   SWISS-2DPAGE; B1XDY3.
KW   Activator; Coiled coil; Cytoplasm; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    133       Sigma factor-binding protein Crl.
FT                                /FTId=PRO_1000138138.
FT   REGION       99    122       Essential for activity.
FT                                {ECO:0000255|HAMAP-Rule:MF_01178}.
FT   COILED       90    116       {ECO:0000255|HAMAP-Rule:MF_01178}.
SQ   SEQUENCE   133 AA;  15655 MW;  EA66172EF19586AA CRC64;
     MTLPSGHPKS RLIKKFTALG PYIREGKCKD NRFFFDCLAV CVNVKPAPEV REFWGWWMEL
     EAQESRFTYS YQFGLFDKAG DWKSVPVKDT EVVERLEHTL REFHEKLREL LTTLNLKLEP
     ADDFRDEPVK LTA
//

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