(data stored in ACNUC7421 zone)

SWISSPROT: ECPA_ECODH

ID   ECPA_ECODH              Reviewed;         195 AA.
AC   B1XE35;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE   AltName: Full=MatB fimbrillin;
DE   Flags: Precursor;
GN   Name=ecpA; Synonyms=matB; OrderedLocusNames=ECDH10B_0281;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition. Major subunit of the fimbria (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by
CC       IHF and EcpR (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family.
CC       {ECO:0000305}.
DR   EMBL; CP000948; ACB01459.1; -; Genomic_DNA.
DR   RefSeq; WP_000730972.1; NC_010473.1.
DR   ProteinModelPortal; B1XE35; -.
DR   SMR; B1XE35; -.
DR   EnsemblBacteria; ACB01459; ACB01459; ECDH10B_0281.
DR   KEGG; ecd:ECDH10B_0281; -.
DR   eggNOG; ENOG4108GWT; Bacteria.
DR   eggNOG; ENOG410ZQ0F; LUCA.
DR   HOGENOM; HOG000269503; -.
DR   OMA; ATWKATA; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR016514; MatB.
DR   Pfam; PF16449; MatB; 1.
DR   PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XE35.
DR   SWISS-2DPAGE; B1XE35.
KW   Fimbrium; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    195       Common pilus major fimbrillin subunit
FT                                EcpA.
FT                                /FTId=PRO_0000367922.
SQ   SEQUENCE   195 AA;  20111 MW;  60791615380A2A44 CRC64;
     MKKKVLAIAL VTVFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
     IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
     DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFSII SGTTNGTTAV TDYSTLPEGI
     WSGDVSVQFD ATWTS
//

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