(data stored in ACNUC7421 zone)

SWISSPROT: BETI_ECODH

ID   BETI_ECODH              Reviewed;         195 AA.
AC   B1XET8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   OrderedLocusNames=ECDH10B_0300;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the
CC       osmoprotectant glycine betaine. It represses transcription of the
CC       choline transporter BetT and the genes of BetAB involved in the
CC       synthesis of glycine betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway [regulation].
DR   EMBL; CP000948; ACB01478.1; -; Genomic_DNA.
DR   RefSeq; WP_001335745.1; NC_010473.1.
DR   SMR; B1XET8; -.
DR   EnsemblBacteria; ACB01478; ACB01478; ECDH10B_0300.
DR   KEGG; ecd:ECDH10B_0300; -.
DR   eggNOG; ENOG4108MHR; Bacteria.
DR   eggNOG; COG1309; LUCA.
DR   HOGENOM; HOG000248227; -.
DR   KO; K02167; -.
DR   OMA; EMEVWFA; -.
DR   BioCyc; ECOL316385:ECDH10B_RS01530-MONOMER; -.
DR   UniPathway; UPA00529; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XET8.
DR   SWISS-2DPAGE; B1XET8.
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN         1    195       HTH-type transcriptional regulator BetI.
FT                                /FTId=PRO_1000190482.
FT   DOMAIN        8     68       HTH tetR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00768}.
FT   DNA_BIND     31     50       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_00768}.
SQ   SEQUENCE   195 AA;  21815 MW;  B52A77B3A605E354 CRC64;
     MPKLGMQSIR RRQLIDATLE AINEVGMHDA TIAQIARRAG VSTGIISHYF RDKNGLLEAT
     MRDITSQLRD AVLNRLHALP QGSAEQRLQA IVGGNFDETQ VSSAAMKAWL AFWASSMHQP
     MLYRLQQVSS RRLLSNLVSE FRRELPREQA QEAGYGLAAL IDGLWLRAAL SGKPLDKTRA
     NSLTRHFITQ HLPTD
//

If you have problems or comments...

PBIL Back to PBIL home page