(data stored in ACNUC7421 zone)

SWISSPROT: IRAP_ECODH

ID   IRAP_ECODH              Reviewed;          86 AA.
AC   B1XEX1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 50.
DE   RecName: Full=Anti-adapter protein IraP {ECO:0000255|HAMAP-Rule:MF_01198};
GN   Name=iraP {ECO:0000255|HAMAP-Rule:MF_01198};
GN   OrderedLocusNames=ECDH10B_0339;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Inhibits RpoS proteolysis by regulating RssB activity,
CC       thereby increasing the stability of the sigma stress factor RpoS
CC       especially during phosphate starvation, but also in stationary
CC       phase and during nitrogen starvation. Its effect on RpoS stability
CC       is due to its interaction with RssB, which probably blocks the
CC       interaction of RssB with RpoS, and the consequent delivery of the
CC       RssB-RpoS complex to the ClpXP protein degradation pathway.
CC       {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SUBUNIT: Interacts with RssB. {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01198}.
CC   -!- SIMILARITY: Belongs to the IraP family. {ECO:0000255|HAMAP-
CC       Rule:MF_01198}.
DR   EMBL; CP000948; ACB01511.1; -; Genomic_DNA.
DR   RefSeq; WP_000792970.1; NC_010473.1.
DR   ProteinModelPortal; B1XEX1; -.
DR   SMR; B1XEX1; -.
DR   EnsemblBacteria; ACB01511; ACB01511; ECDH10B_0339.
DR   KEGG; ecd:ECDH10B_0339; -.
DR   eggNOG; ENOG4105RZQ; Bacteria.
DR   eggNOG; ENOG4111YMR; LUCA.
DR   HOGENOM; HOG000059299; -.
DR   OMA; NSIDTAM; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01198; Anti_adapt_IraP; 1.
DR   InterPro; IPR019732; SigmaS_Anti-adapt_IraP.
DR   Pfam; PF10796; Anti-adapt_IraP; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XEX1.
DR   SWISS-2DPAGE; B1XEX1.
KW   Coiled coil; Cytoplasm; Stress response.
FT   CHAIN         1     86       Anti-adapter protein IraP.
FT                                /FTId=PRO_1000138485.
FT   COILED        1     36       {ECO:0000255|HAMAP-Rule:MF_01198}.
SQ   SEQUENCE   86 AA;  9937 MW;  1C2EE018BFB16BEE CRC64;
     MKNLIAELLF KLAQKEEESK ELCAQVEALE IIVTAMLRNM AQNDQQRLID QVEGALYEVK
     PDASIPDDDT ELLRDYVKKL LKHPRQ
//

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