(data stored in ACNUC7421 zone)

SWISSPROT: NRDR_ECODH

ID   NRDR_ECODH              Reviewed;         149 AA.
AC   B1XF01;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 61.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   OrderedLocusNames=ECDH10B_0369;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
DR   EMBL; CP000948; ACB01541.1; -; Genomic_DNA.
DR   RefSeq; WP_000543535.1; NC_010473.1.
DR   ProteinModelPortal; B1XF01; -.
DR   EnsemblBacteria; ACB01541; ACB01541; ECDH10B_0369.
DR   KEGG; ecd:ECDH10B_0369; -.
DR   eggNOG; ENOG4108Z11; Bacteria.
DR   eggNOG; COG1327; LUCA.
DR   HOGENOM; HOG000097653; -.
DR   KO; K07738; -.
DR   OMA; RFTTYET; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   PANTHER; PTHR30455:SF3; PTHR30455:SF3; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   TIGRFAMs; TIGR00244; TIGR00244; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1XF01.
DR   SWISS-2DPAGE; B1XF01.
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    149       Transcriptional repressor NrdR.
FT                                /FTId=PRO_1000124502.
FT   DOMAIN       49    139       ATP-cone. {ECO:0000255|HAMAP-
FT                                Rule:MF_00440}.
FT   ZN_FING       3     34       {ECO:0000255|HAMAP-Rule:MF_00440}.
SQ   SEQUENCE   149 AA;  17229 MW;  EFF99DD555EF2D26 CRC64;
     MHCPFCFAVD TKVIDSRLVG EGSSVRRRRQ CLVCNERFTT FEVAELVMPR VVKSNDVREP
     FNEEKLRSGM LRALEKRPVS SDDVEMAINH IKSQLRATGE REVPSKMIGN LVMEQLKKLD
     KVAYIRFASV YRSFEDIKEF GEEIARLED
//

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