(data stored in ACNUC7421 zone)

SWISSPROT: ALLA_ECODH

ID   ALLA_ECODH              Reviewed;         160 AA.
AC   B1XFU0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   05-JUL-2017, entry version 60.
DE   RecName: Full=Ureidoglycolate lyase {ECO:0000255|HAMAP-Rule:MF_00616};
DE            EC=4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616};
DE   AltName: Full=Ureidoglycolatase {ECO:0000255|HAMAP-Rule:MF_00616};
DE   AltName: Full=Ureidoglycolate hydrolase;
GN   Name=allA {ECO:0000255|HAMAP-Rule:MF_00616};
GN   OrderedLocusNames=ECDH10B_0461;
OS   Escherichia coli (strain K12 / DH10B).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=316385;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / DH10B;
RX   PubMed=18245285; DOI=10.1128/JB.01695-07;
RA   Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA   Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA   Posfai G., Weinstock G.M., Blattner F.R.;
RT   "The complete genome sequence of Escherichia coli DH10B: insights into
RT   the biology of a laboratory workhorse.";
RL   J. Bacteriol. 190:2597-2606(2008).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RC   STRAIN=K12 / DH10B;
RX   PubMed=19935661; DOI=10.1038/nchembio.265;
RA   Werner A.K., Romeis T., Witte C.P.;
RT   "Ureide catabolism in Arabidopsis thaliana and Escherichia coli.";
RL   Nat. Chem. Biol. 6:19-21(2010).
CC   -!- FUNCTION: Catalyzes the catabolism of the allantoin degradation
CC       intermediate (S)-ureidoglycolate, generating urea and glyoxylate.
CC       Involved in the anaerobic utilization of allantoin as sole
CC       nitrogen source. Reinforces the induction of genes involved in the
CC       degradation of allantoin and glyoxylate by producing glyoxylate.
CC       {ECO:0000255|HAMAP-Rule:MF_00616, ECO:0000269|PubMed:19935661}.
CC   -!- CATALYTIC ACTIVITY: (S)-ureidoglycolate = glyoxylate + urea.
CC       {ECO:0000255|HAMAP-Rule:MF_00616, ECO:0000269|PubMed:19935661}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00616};
CC   -!- PATHWAY: Nitrogen metabolism; (S)-allantoin degradation.
CC       {ECO:0000255|HAMAP-Rule:MF_00616}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00616}.
CC   -!- SIMILARITY: Belongs to the ureidoglycolate lyase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00616}.
DR   EMBL; CP000948; ACB01630.1; -; Genomic_DNA.
DR   RefSeq; WP_000776377.1; NC_010473.1.
DR   ProteinModelPortal; B1XFU0; -.
DR   SMR; B1XFU0; -.
DR   EnsemblBacteria; ACB01630; ACB01630; ECDH10B_0461.
DR   KEGG; ecd:ECDH10B_0461; -.
DR   eggNOG; ENOG4108Z2U; Bacteria.
DR   eggNOG; COG3194; LUCA.
DR   HOGENOM; HOG000256169; -.
DR   KO; K01483; -.
DR   OMA; NCDIFQF; -.
DR   UniPathway; UPA00395; -.
DR   GO; GO:0004848; F:ureidoglycolate hydrolase activity; IEA:InterPro.
DR   GO; GO:0050385; F:ureidoglycolate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000256; P:allantoin catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.480; -; 1.
DR   HAMAP; MF_00616; Ureidogly_lyase; 1.
DR   InterPro; IPR011051; RmlC_Cupin.
DR   InterPro; IPR007247; Ureidogly_lyase.
DR   InterPro; IPR023525; Ureidogly_lyase_bac.
DR   InterPro; IPR024060; Ureidoglycolate_lyase_dom.
DR   PANTHER; PTHR21221; PTHR21221; 1.
DR   Pfam; PF04115; Ureidogly_lyase; 1.
DR   PIRSF; PIRSF017306; Ureidogly_hydro; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   1: Evidence at protein level;
DR   PRODOM; B1XFU0.
DR   SWISS-2DPAGE; B1XFU0.
KW   Lyase; Purine metabolism.
FT   CHAIN         1    160       Ureidoglycolate lyase.
FT                                /FTId=PRO_1000130414.
SQ   SEQUENCE   160 AA;  18170 MW;  88FDA2A7D48D6E97 CRC64;
     MKLQVLPLSQ EAFSAYGDVI ETQQRDFFHI NNGLVERYHD LALVEILEQD CTLISINRAQ
     PANLPLTIHE LERHPLGTQA FIPMKGEVFV VVVALGDDKP DLSTLRAFIT NGEQGVNYHR
     NVWHHPLFAW QRVTDFLTID RGGSDNCDVE SIPEQELCFA
//

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