(data stored in ACNUC29543 zone)

SWISSPROT: B2JL24_PARP8

ID   B2JL24_PARP8            Unreviewed;       356 AA.
AC   B2JL24;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   08-MAY-2019, entry version 73.
DE   RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE            EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN   OrderedLocusNames=Bphy_3399 {ECO:0000313|EMBL:ACC72553.1};
OS   Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS   STM815) (Burkholderia phymatum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=391038 {ECO:0000313|EMBL:ACC72553.1, ECO:0000313|Proteomes:UP000001192};
RN   [1] {ECO:0000313|Proteomes:UP000001192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815
RC   {ECO:0000313|Proteomes:UP000001192};
RX   PubMed=25197461; DOI=10.4056/sigs.4861021;
RA   Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A.,
RA   Melkonian R., James E.K., Young J.P., Bena G., Hauser L., Land M.,
RA   Kyrpides N., Bruce D., Chain P., Copeland A., Pitluck S., Woyke T.,
RA   Lizotte-Waniewski M., Bristow J., Riley M.;
RT   "Complete genome sequence of Burkholderia phymatum STM815(T), a broad
RT   host range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL   Stand. Genomic Sci. 9:763-774(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a
CC         5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369,
CC         Rhea:RHEA-COMP:11370, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:85452, ChEBI:CHEBI:85454;
CC         EC=2.1.1.37; Evidence={ECO:0000256|RuleBase:RU000417};
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. C5-methyltransferase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01016,
CC       ECO:0000256|RuleBase:RU000416}.
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DR   EMBL; CP001044; ACC72553.1; -; Genomic_DNA.
DR   RefSeq; WP_012402726.1; NC_010623.1.
DR   STRING; 391038.Bphy_3399; -.
DR   REBASE; 17903; M1.BphSTMORF3399P.
DR   EnsemblBacteria; ACC72553; ACC72553; Bphy_3399.
DR   GeneID; 27743083; -.
DR   KEGG; bph:Bphy_3399; -.
DR   eggNOG; ENOG4105NI8; Bacteria.
DR   eggNOG; COG0270; LUCA.
DR   HOGENOM; HOG000000535; -.
DR   KO; K00558; -.
DR   OMA; TIFMSRN; -.
DR   OrthoDB; 1178320at2; -.
DR   BioCyc; BPHY391038:G1GBS-3498-MONOMER; -.
DR   Proteomes; UP000001192; Chromosome 2.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF00145; DNA_methylase; 2.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00675; dcm; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
DR   PRODOM; B2JL24.
DR   SWISS-2DPAGE; B2JL24.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001192};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000256|RuleBase:RU000417, ECO:0000313|EMBL:ACC72553.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001192};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000256|RuleBase:RU000417, ECO:0000313|EMBL:ACC72553.1}.
FT   ACT_SITE    102    102       {ECO:0000256|PROSITE-ProRule:PRU01016}.
SQ   SEQUENCE   356 AA;  39196 MW;  78918F93B6334076 CRC64;
     MAYHDRLAVA WESHLAPRAP DAPTVVSTFA GCGGSSLGYS MAGFDERLAV EWNEKQAASF
     VANFPHVPLH LGDIADLSDA DALRMARLEP GELDVFDGSP PCQGFSLAGA RKFQDGRNQL
     FIEYVRLLRT FAPKAFVMEN VRGMVVGKMR LIFADILNEL KGCGYTVCAR VLTAGYYGVP
     QMRPRMIFIG IRNDLAACGV LPSHPEPQCW PPCVAEAWHG VANTPDEIEA AAFAQTRLVW
     RLLWRMKPGE YGDEYHPNKQ LYGLYRLDPA RPSPTILRNG GAGGACEACH PTEHRRITIA
     EAKRIGSFPD PFVLRGNFQE RWAAIGNCVP PLFMRAIALH VRGLLETASE HHAATA
//

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