(data stored in ACNUC7421 zone)

SWISSPROT: B2TF16_PARPJ

ID   B2TF16_PARPJ            Unreviewed;       212 AA.
AC   B2TF16;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   RecName: Full=GTP cyclohydrolase 1 {ECO:0000256|HAMAP-Rule:MF_00223};
DE            EC=3.5.4.16 {ECO:0000256|HAMAP-Rule:MF_00223};
DE   AltName: Full=GTP cyclohydrolase I {ECO:0000256|HAMAP-Rule:MF_00223};
DE            Short=GTP-CH-I {ECO:0000256|HAMAP-Rule:MF_00223};
GN   Name=folE {ECO:0000256|HAMAP-Rule:MF_00223};
GN   OrderedLocusNames=Bphyt_4310 {ECO:0000313|EMBL:ACD18687.1};
OS   Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)
OS   (Burkholderia phytofirmans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=398527 {ECO:0000313|EMBL:ACD18687.1, ECO:0000313|Proteomes:UP000001739};
RN   [1] {ECO:0000313|EMBL:ACD18687.1, ECO:0000313|Proteomes:UP000001739}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17436 / LMG 22146 / PsJN
RC   {ECO:0000313|Proteomes:UP000001739};
RX   PubMed=21551308; DOI=10.1128/JB.05055-11;
RA   Weilharter A., Mitter B., Shin M.V., Chain P.S., Nowak J.,
RA   Sessitsch A.;
RT   "Complete genome sequence of the plant growth-promoting endophyte
RT   Burkholderia phytofirmans strain PsJN.";
RL   J. Bacteriol. 193:3383-3384(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate +
CC         formate + H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:58462; EC=3.5.4.16; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00223, ECO:0000256|SAAS:SAAS01118752};
CC   -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate
CC       biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step
CC       1/1. {ECO:0000256|HAMAP-Rule:MF_00223,
CC       ECO:0000256|SAAS:SAAS00021202}.
CC   -!- SUBUNIT: Homopolymer. {ECO:0000256|HAMAP-Rule:MF_00223}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family.
CC       {ECO:0000256|HAMAP-Rule:MF_00223, ECO:0000256|SAAS:SAAS00673743}.
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DR   EMBL; CP001053; ACD18687.1; -; Genomic_DNA.
DR   RefSeq; WP_012426203.1; NC_010676.1.
DR   STRING; 398527.Bphyt_4310; -.
DR   EnsemblBacteria; ACD18687; ACD18687; Bphyt_4310.
DR   KEGG; bpy:Bphyt_4310; -.
DR   eggNOG; ENOG4105EUJ; Bacteria.
DR   eggNOG; COG0302; LUCA.
DR   HOGENOM; HOG000221222; -.
DR   KO; K01495; -.
DR   OMA; IVVVECE; -.
DR   OrthoDB; 1632367at2; -.
DR   UniPathway; UPA00848; UER00151.
DR   Proteomes; UP000001739; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00223; FolE; 1.
DR   InterPro; IPR001474; GTP_CycHdrlase_I.
DR   InterPro; IPR018234; GTP_CycHdrlase_I_CS.
DR   InterPro; IPR020602; GTP_CycHdrlase_I_dom.
DR   PANTHER; PTHR11109; PTHR11109; 1.
DR   Pfam; PF01227; GTP_cyclohydroI; 1.
DR   TIGRFAMs; TIGR00063; folE; 1.
DR   PROSITE; PS00859; GTP_CYCLOHYDROL_1_1; 1.
DR   PROSITE; PS00860; GTP_CYCLOHYDROL_1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B2TF16.
DR   SWISS-2DPAGE; B2TF16.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001739};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00223};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00223,
KW   ECO:0000256|SAAS:SAAS00021177, ECO:0000313|EMBL:ACD18687.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00223,
KW   ECO:0000256|SAAS:SAAS00021169};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00223};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00223,
KW   ECO:0000256|SAAS:SAAS00021243};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00223, ECO:0000256|SAAS:SAAS00021207}.
FT   DOMAIN       24    201       GTP_cyclohydroI. {ECO:0000259|Pfam:
FT                                PF01227}.
FT   METAL        94     94       Zinc. {ECO:0000256|HAMAP-Rule:MF_00223}.
FT   METAL        97     97       Zinc. {ECO:0000256|HAMAP-Rule:MF_00223}.
FT   METAL       165    165       Zinc. {ECO:0000256|HAMAP-Rule:MF_00223}.
SQ   SEQUENCE   212 AA;  23564 MW;  5DFEDF3A4700812B CRC64;
     MTSSKAKKTK PITATERPSR EEAEAAVRVL LRWAGDDPAR EGLIDTPARV VRSYEEFYAG
     YQVDPREILA RTFSEVDGYD EMIVLKDIRF ESYCEHHMVP IIGRAHVAYL PQHRVVGISK
     LARLVDAFAK RLQIQEKMTV QIADTLNEVL QPAGVGVILE AAHQCMSTRG VHKAGVTMVT
     SRMLGTFRTD PSTRREFLSI VGNPGVVAVA NT
//

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