(data stored in ACNUC7421 zone)

SWISSPROT: B2TFC8_PARPJ

ID   B2TFC8_PARPJ            Unreviewed;       311 AA.
AC   B2TFC8;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   08-MAY-2019, entry version 78.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|RuleBase:RU362068};
DE            EC=1.1.1.169 {ECO:0000256|RuleBase:RU362068};
DE   AltName: Full=Ketopantoate reductase {ECO:0000256|RuleBase:RU362068};
DE   Flags: Precursor;
GN   OrderedLocusNames=Bphyt_4423 {ECO:0000313|EMBL:ACD18799.1};
OS   Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)
OS   (Burkholderia phytofirmans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=398527 {ECO:0000313|EMBL:ACD18799.1, ECO:0000313|Proteomes:UP000001739};
RN   [1] {ECO:0000313|EMBL:ACD18799.1, ECO:0000313|Proteomes:UP000001739}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17436 / LMG 22146 / PsJN
RC   {ECO:0000313|Proteomes:UP000001739};
RX   PubMed=21551308; DOI=10.1128/JB.05055-11;
RA   Weilharter A., Mitter B., Shin M.V., Chain P.S., Nowak J.,
RA   Sessitsch A.;
RT   "Complete genome sequence of the plant growth-promoting endophyte
RT   Burkholderia phytofirmans strain PsJN.";
RL   J. Bacteriol. 193:3383-3384(2011).
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate
CC       into pantoic acid. {ECO:0000256|RuleBase:RU362068}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) +
CC         NADPH; Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15980, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.1.1.169;
CC         Evidence={ECO:0000256|RuleBase:RU362068};
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis;
CC       (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC       {ECO:0000256|RuleBase:RU362068}.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|RuleBase:RU362068}.
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DR   EMBL; CP001053; ACD18799.1; -; Genomic_DNA.
DR   RefSeq; WP_012426315.1; NC_010676.1.
DR   STRING; 398527.Bphyt_4423; -.
DR   EnsemblBacteria; ACD18799; ACD18799; Bphyt_4423.
DR   KEGG; bpy:Bphyt_4423; -.
DR   eggNOG; ENOG4108KF8; Bacteria.
DR   eggNOG; COG1893; LUCA.
DR   HOGENOM; HOG000050222; -.
DR   KO; K00077; -.
DR   OMA; EMWEKWV; -.
DR   OrthoDB; 427052at2; -.
DR   BioCyc; BPHY398527:GJEX-4413-MONOMER; -.
DR   UniPathway; UPA00028; UER00004.
DR   Proteomes; UP000001739; Chromosome 2.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00745; apbA_panE; 1.
PE   3: Inferred from homology;
DR   PRODOM; B2TFC8.
DR   SWISS-2DPAGE; B2TFC8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001739};
KW   NADP {ECO:0000256|RuleBase:RU362068};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU362068,
KW   ECO:0000313|EMBL:ACD18799.1};
KW   Pantothenate biosynthesis {ECO:0000256|RuleBase:RU362068}.
FT   DOMAIN        3    150       ApbA. {ECO:0000259|Pfam:PF02558}.
FT   DOMAIN      178    281       ApbA_C. {ECO:0000259|Pfam:PF08546}.
SQ   SEQUENCE   311 AA;  33141 MW;  30C93B3BB88EE6C9 CRC64;
     MRILVVGAGA VGGYFGGRLA AAGQDVTFLV RPGRAEKLKR DGLVISSVRG DLKLPDPQTI
     LAGVSAEPFD LVLLSCKAFS LDDAIDSFAP LVGESTLILP MLNGMRHMEV LNEKFGAARV
     LGGQCVIAAT LNAEQHIVHL NDTHAITFGE QAGGASERVQ AIAEAMGDAN FDAVISDNIL
     LRMWEKWVFL ATLAGGTCLM RGSVGDILAA PDGKRVIENL LGECRAVAEH NGFTMGPDFD
     ARATQTLFTP SPLTASMLRD VENHSHTEAD HILGDLISRG GDAQKGEHGL SLLRIAYSHL
     KTYEARQART S
//

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