(data stored in ACNUC7421 zone)

SWISSPROT: B2UHC2_RALPJ

ID   B2UHC2_RALPJ            Unreviewed;       865 AA.
AC   B2UHC2;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   SubName: Full=2-methylisocitrate dehydratase, Fe/S-dependent {ECO:0000313|EMBL:ACD28973.1};
DE            EC=4.2.1.3 {ECO:0000313|EMBL:ACD28973.1};
GN   OrderedLocusNames=Rpic_3859 {ECO:0000313|EMBL:ACD28973.1};
OS   Ralstonia pickettii (strain 12J).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=402626 {ECO:0000313|EMBL:ACD28973.1, ECO:0000313|Proteomes:UP000002566};
RN   [1] {ECO:0000313|Proteomes:UP000002566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12J {ECO:0000313|Proteomes:UP000002566};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T.,
RA   Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Marsh T., Richardson P.;
RT   "Complete sequence of chromosome 2 of Ralstonia pickettii 12J.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001069; ACD28973.1; -; Genomic_DNA.
DR   RefSeq; WP_012430017.1; NC_010678.1.
DR   STRING; 402626.Rpic_3859; -.
DR   EnsemblBacteria; ACD28973; ACD28973; Rpic_3859.
DR   GeneID; 6284962; -.
DR   KEGG; rpi:Rpic_3859; -.
DR   PATRIC; fig|402626.5.peg.101; -.
DR   eggNOG; ENOG4107QM5; Bacteria.
DR   eggNOG; COG1048; LUCA.
DR   HOGENOM; HOG000025703; -.
DR   KO; K20455; -.
DR   OMA; INLERMS; -.
DR   OrthoDB; 363064at2; -.
DR   BioCyc; RPIC402626:GH94-3869-MONOMER; -.
DR   Proteomes; UP000002566; Chromosome 2.
DR   GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019679; P:propionate metabolic process, methylcitrate cycle; IEA:InterPro.
DR   Gene3D; 3.20.19.10; -; 1.
DR   Gene3D; 3.30.499.10; -; 1.
DR   InterPro; IPR012708; 2Me_IsoCit_deHydtase_FeS-dep.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   PANTHER; PTHR11670; PTHR11670; 1.
DR   PANTHER; PTHR11670:SF43; PTHR11670:SF43; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; SSF53732; 1.
DR   TIGRFAMs; TIGR02333; 2met_isocit_dHY; 1.
PE   4: Predicted;
DR   PRODOM; B2UHC2.
DR   SWISS-2DPAGE; B2UHC2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002566};
KW   Lyase {ECO:0000313|EMBL:ACD28973.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002566}.
FT   DOMAIN       70    533       Aconitase. {ECO:0000259|Pfam:PF00330}.
FT   DOMAIN      657    787       Aconitase_C. {ECO:0000259|Pfam:PF00694}.
SQ   SEQUENCE   865 AA;  94659 MW;  F77B9E251AEC1E77 CRC64;
     MNTTHRKPLP GTKLDYFDAR EAVEAIKQGA YDKLPYTSRV LAENLVRRCD PATLTDSLKQ
     LIERKRDLDF PWFPARVVCH DILGQTALVD LAGLRDAIAD QGGDPAKVNP VVPVQLIVDH
     SLAVECGGFD PDAFAKNRAI EDRRNEDRFH FIDWTKLAFK NVDVIPAGNG IMHQINLEKM
     SPVIQAHDGV AYPDTCVGTD SHTPHVDALG VIAIGVGGLE AENVMLGRAS WMRLPDIVGV
     ELTGQRQPGI TATDIVLALT EFLRKQKVVG AYLEFYGEGA SKLTLGDRAT ISNMAPEYGA
     TAAMFSIDDN TLDYLRLTGR TDEQVKLVET YAKTAGLWSD TLKHAEYERV LRFDLSSVVR
     NMAGPSNPHA RVATTDLAAK GIAGKWEETP GQMPDGAVII AAITSCTNTS NPRNVIAAAL
     LARNANRLGL TRKPWVKSSL APGSKAVELY LEEAGLKHEL EKLGFGIVAF ACTTCNGMSG
     ALDPKIQQEI IDRDLYATAV LSGNRNFDGR IHPYAKQAFL ASPPLVVAYA IAGTVRFDIE
     RDSFGTDANG KPILLKDLWP TDEEIDAIVR ASVKPEQFRT VYIPMFEQRS ESTAKVSPLY
     NWRPQSTYIR RPPYWEGALA GERTLKGLRP LAVLGDNITT DHLSPSNAIL ASSAAGEYLA
     KMGLPEEDFN SYATHRGDHL TAQRATFANP TLINEMAVVD GAVKKGSLAR IEPEGKVTRM
     WEAIETYMDR KQPLIVIAGA DYGQGSSRDW AAKGVRLAGV EAIVAEGFER IHRTNLIGMG
     VLPLEFKPGT TRLTLSIDGT ETYDVIGERK PRADLTLVIH RKNGERVEVP VTCRLDSDEE
     VSIYEAGGVL QRFAQDFLES SKEAA
//

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