(data stored in ACNUC7421 zone)

SWISSPROT: B4SRV8_STRM5

ID   B4SRV8_STRM5            Unreviewed;       482 AA.
AC   B4SRV8;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-MAY-2019, entry version 84.
DE   RecName: Full=DNA-binding transcriptional regulator NtrC {ECO:0000256|RuleBase:RU365013};
DE   AltName: Full=Nitrogen regulation protein NR(I) {ECO:0000256|RuleBase:RU365013};
GN   Name=ntrC {ECO:0000256|RuleBase:RU365013};
GN   OrderedLocusNames=Smal_0123 {ECO:0000313|EMBL:ACF49828.1};
OS   Stenotrophomonas maltophilia (strain R551-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas;
OC   Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=391008 {ECO:0000313|EMBL:ACF49828.1, ECO:0000313|Proteomes:UP000001867};
RN   [1] {ECO:0000313|EMBL:ACF49828.1, ECO:0000313|Proteomes:UP000001867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R551-3 {ECO:0000313|EMBL:ACF49828.1,
RC   ECO:0000313|Proteomes:UP000001867};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L.,
RA   Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Taghavi S., Monchy S., Newman L., Vangronsveld J.,
RA   van der Lelie D., Richardson P.;
RT   "Complete sequence of Stenotrophomonas maltophilia R551-3.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system NtrB/NtrC,
CC       which controls expression of the nitrogen-regulated (ntr) genes in
CC       response to nitrogen limitation. Phosphorylated NtrC binds
CC       directly to DNA and stimulates the formation of open promoter-
CC       sigma54-RNA polymerase complexes. {ECO:0000256|RuleBase:RU365013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365013}.
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DR   EMBL; CP001111; ACF49828.1; -; Genomic_DNA.
DR   RefSeq; WP_012509690.1; NC_011071.1.
DR   STRING; 391008.Smal_0123; -.
DR   EnsemblBacteria; ACF49828; ACF49828; Smal_0123.
DR   KEGG; smt:Smal_0123; -.
DR   eggNOG; ENOG4105C1W; Bacteria.
DR   eggNOG; COG2204; LUCA.
DR   HOGENOM; HOG000058489; -.
DR   KO; K07712; -.
DR   OMA; DWTGNIR; -.
DR   OrthoDB; 123059at2; -.
DR   BioCyc; SMAL391008:SMAL_RS00615-MONOMER; -.
DR   Proteomes; UP000001867; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   GO; GO:0006808; P:regulation of nitrogen utilization; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00156; REC; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   InterPro; IPR010114; Trancript_reg_NtrC.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   PRINTS; PR01590; HTHFIS.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01818; ntrC; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   4: Predicted;
DR   PRODOM; B4SRV8.
DR   SWISS-2DPAGE; B4SRV8.
KW   Activator {ECO:0000256|RuleBase:RU365013};
KW   ATP-binding {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00473007};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001867};
KW   Cytoplasm {ECO:0000256|RuleBase:RU365013};
KW   DNA-binding {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00421512};
KW   Nitrogen fixation {ECO:0000256|RuleBase:RU365013};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00473126};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Repressor {ECO:0000256|RuleBase:RU365013};
KW   Transcription {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00814760};
KW   Transcription regulation {ECO:0000256|RuleBase:RU365013,
KW   ECO:0000256|SAAS:SAAS00814754};
KW   Two-component regulatory system {ECO:0000256|RuleBase:RU365013}.
FT   DOMAIN       10    125       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      149    378       Sigma-54 factor interaction.
FT                                {ECO:0000259|PROSITE:PS50045}.
FT   MOD_RES      60     60       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   482 AA;  51875 MW;  AC7190B55621D0EE CRC64;
     MSDASTPAQR IWVVDDDRAV RFVLCTALRE AGYQVVDFDS AAPALQALSE GPPPALLFTD
     VRMPGDDGLV LLDKLKAVLP QLPVVVMSAY TDVASTAGAF RGGAHEFLSK PFDLDDAVAL
     AQRVLPAVAP AMAAAAPTTA TSSDQPPQLV GDTPPMRALF RAIGRLAQAP LAVLITGETG
     TGKELVAHAL HRESPRAQAP FVALNTAAIP AELLESELFG HEAGAFTGAQ RRHIGRFEQA
     NGGTLFLDEI GDMPLPLQTR LLRVLAQGEF FRVGGRELIR VDVRVVAATH QDLEGLVAQG
     KFRADLLHRL DVVRLQLPPL RERREDIAQL ANTFLAAAAR KLDTPPKRLT AAALQALREH
     DWPGNVRELE NVCWRMAALA AADTIGVADV DTALNRTRGR RSSTTSADPG QWEALLAEWA
     RRQLAEGVEG LHAQVRERVD HALLEAALQI THGRRAEAAA RLGLGRNTLT RKLGAGRRRG
     GH
//

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