(data stored in ACNUC7421 zone)

SWISSPROT: B4SID3_STRM5

ID   B4SID3_STRM5            Unreviewed;       549 AA.
AC   B4SID3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:ACF50138.1};
GN   OrderedLocusNames=Smal_0433 {ECO:0000313|EMBL:ACF50138.1};
OS   Stenotrophomonas maltophilia (strain R551-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas;
OC   Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=391008 {ECO:0000313|EMBL:ACF50138.1, ECO:0000313|Proteomes:UP000001867};
RN   [1] {ECO:0000313|EMBL:ACF50138.1, ECO:0000313|Proteomes:UP000001867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R551-3 {ECO:0000313|EMBL:ACF50138.1,
RC   ECO:0000313|Proteomes:UP000001867};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L.,
RA   Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Taghavi S., Monchy S., Newman L., Vangronsveld J.,
RA   van der Lelie D., Richardson P.;
RT   "Complete sequence of Stenotrophomonas maltophilia R551-3.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC       (CPA1) transporter (TC 2.A.36) family.
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; CP001111; ACF50138.1; -; Genomic_DNA.
DR   RefSeq; WP_012509929.1; NC_011071.1.
DR   STRING; 391008.Smal_0433; -.
DR   EnsemblBacteria; ACF50138; ACF50138; Smal_0433.
DR   KEGG; smt:Smal_0433; -.
DR   eggNOG; ENOG4105EEQ; Bacteria.
DR   eggNOG; COG0025; LUCA.
DR   HOGENOM; HOG000263347; -.
DR   KO; K03316; -.
DR   OMA; AGMMMNY; -.
DR   OrthoDB; 1194802at2; -.
DR   BioCyc; SMAL391008:SMAL_RS02230-MONOMER; -.
DR   Proteomes; UP000001867; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   InterPro; IPR004709; NaH_exchanger.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
DR   PRODOM; B4SID3.
DR   SWISS-2DPAGE; B4SID3.
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|RuleBase:RU366002};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001867};
KW   Ion transport {ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM      6     24       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     31     49       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     55     72       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     84    105       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    111    135       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    156    177       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    183    204       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    216    234       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    240    259       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    271    292       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    312    335       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    356    383       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    395    415       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   DOMAIN       10    420       Na_H_Exchanger. {ECO:0000259|Pfam:
FT                                PF00999}.
SQ   SEQUENCE   549 AA;  60086 MW;  1784C50599216CF1 CRC64;
     MHTIEVVLAM LVAVVASGYL VRVLPFSLPL PLVQIGLGAV IAGVFNRGHA LEPEVFFLLF
     LPPLLFLDGW RIPKQGLFRD KGAILELAFG LVVFTVIGAG LLIHWMIPVM PLAVCFALAA
     IVSPTDPVAV GAIASKAPIP KRLMHILEGE SLLNDASGLV CFRFAVAAVM TGTFSLATAS
     LTFLWVAVAG LAVGVAVTLG VSTFQRWLWR RFGEEPGAAM LVNLLIPFAA YLLAEEINAS
     GILAAVAAGI SMSYVEMTGR VSGSMRVQRA GVWNMLQFSF NGIMFVLLGE QLPGIVERAT
     TTMNESGHQS AWWLLVYVLV INATLITLRL LWVWLSLRWN LLRARRRGLE RGEAPNWRIV
     VATSVAGVRG AITLAGVLTL PLFLPDGSPF PARDLVIFLA AAVILFSLVG ASVALPQLLK
     GLQLPADSGE RKEEDLARRL SSKAALAGVE RMRQQMVMNQ NTENVQLYND AASRVSLLYQ
     RHLEKDSDGP DVDPEKVQRM ELGYRQLRSA GLNAEREELF RLTRRGVISD EISRRLIRNL
     DLLESRKRE
//

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