(data stored in ACNUC7421 zone)

SWISSPROT: B4SJ40_STRM5

ID   B4SJ40_STRM5            Unreviewed;       351 AA.
AC   B4SJ40;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   OrderedLocusNames=Smal_0503 {ECO:0000313|EMBL:ACF50208.1};
OS   Stenotrophomonas maltophilia (strain R551-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Stenotrophomonas;
OC   Stenotrophomonas maltophilia group.
OX   NCBI_TaxID=391008 {ECO:0000313|EMBL:ACF50208.1, ECO:0000313|Proteomes:UP000001867};
RN   [1] {ECO:0000313|EMBL:ACF50208.1, ECO:0000313|Proteomes:UP000001867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R551-3 {ECO:0000313|EMBL:ACF50208.1,
RC   ECO:0000313|Proteomes:UP000001867};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L.,
RA   Lang D., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Taghavi S., Monchy S., Newman L., Vangronsveld J.,
RA   van der Lelie D., Richardson P.;
RT   "Complete sequence of Stenotrophomonas maltophilia R551-3.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-
CC         glucose + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:57477, ChEBI:CHEBI:57649; EC=4.2.1.46;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|RuleBase:RU004473}.
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DR   EMBL; CP001111; ACF50208.1; -; Genomic_DNA.
DR   RefSeq; WP_012509980.1; NC_011071.1.
DR   STRING; 391008.Smal_0503; -.
DR   EnsemblBacteria; ACF50208; ACF50208; Smal_0503.
DR   KEGG; smt:Smal_0503; -.
DR   eggNOG; ENOG4105C1B; Bacteria.
DR   eggNOG; COG1088; LUCA.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OMA; GWNEKPN; -.
DR   OrthoDB; 707977at2; -.
DR   BioCyc; SMAL391008:SMAL_RS02575-MONOMER; -.
DR   Proteomes; UP000001867; Chromosome.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   CDD; cd05246; dTDP_GD_SDR_e; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
DR   PRODOM; B4SJ40.
DR   SWISS-2DPAGE; B4SJ40.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001867};
KW   Lyase {ECO:0000256|RuleBase:RU004473}.
FT   DOMAIN        5    321       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   351 AA;  38492 MW;  66ADD37DAC536077 CRC64;
     MPTWLVTGGA GFIGGNFVLE AVARGVKVIN LDVLTYAGNL KTLSSLDGNP NHLFVQGDIG
     DRELVTRLLA EHRPDAVLNF AAESHVDRSI DVPGAFIQTN VVGTLGLLEA VRDYWKALPA
     EQGADFRFLH VSTDEVYGTL GETGKFSETT PYAPNSPYSA SKAASDHLVR AFHHTYGLPV
     LTTNCSNNYG PYHFPEKLIP LVIAKALAGE PLPVYGDGKQ VRDWLFVSDH CEAIRTVLAK
     GQVGETYNVG GNSEKQNIEV VQAICALLDA RRPREDGQPR SSQITYVADR PGHDRRYAID
     ASKLKNDLGW EPAYTFEQGI TFTVDWYLDN QEWVNGVLDG SYRLQRIGTA G
//

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