(data stored in ACNUC7421 zone)

SWISSPROT: B8IUD3_METNO

ID   B8IUD3_METNO            Unreviewed;       449 AA.
AC   B8IUD3;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   30-AUG-2017, entry version 64.
DE   RecName: Full=C4-dicarboxylate transport protein {ECO:0000256|HAMAP-Rule:MF_01300};
GN   Name=dctA {ECO:0000256|HAMAP-Rule:MF_01300};
GN   OrderedLocusNames=Mnod_0132 {ECO:0000313|EMBL:ACL55178.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55178.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55178.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC       succinate, fumarate, and malate from the periplasm across the
CC       membrane. {ECO:0000256|HAMAP-Rule:MF_01300}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01300}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01300}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation
CC       symporter (DAACS) (TC 2.A.23) family. {ECO:0000256|HAMAP-
CC       Rule:MF_01300, ECO:0000256|SAAS:SAAS00632327}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01300}.
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DR   EMBL; CP001349; ACL55178.1; -; Genomic_DNA.
DR   RefSeq; WP_015926891.1; NC_011894.1.
DR   ProteinModelPortal; B8IUD3; -.
DR   STRING; 460265.Mnod_0132; -.
DR   EnsemblBacteria; ACL55178; ACL55178; Mnod_0132.
DR   KEGG; mno:Mnod_0132; -.
DR   eggNOG; ENOG4105CK2; Bacteria.
DR   eggNOG; COG1301; LUCA.
DR   HOGENOM; HOG000208775; -.
DR   KO; K11103; -.
DR   OMA; YLYIAVI; -.
DR   OrthoDB; POG091H06ON; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   HAMAP; MF_01300; C4_dicarb_transport; 1.
DR   InterPro; IPR023954; C4_dicarb_transport.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   Pfam; PF00375; SDF; 1.
DR   PRINTS; PR00173; EDTRNSPORT.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8IUD3.
DR   SWISS-2DPAGE; B8IUD3.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01300};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300,
KW   ECO:0000256|SAAS:SAAS00632335};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01300,
KW   ECO:0000256|SAAS:SAAS00779879};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW   Symport {ECO:0000256|HAMAP-Rule:MF_01300,
KW   ECO:0000256|SAAS:SAAS00632323};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01300,
KW   ECO:0000256|SAAS:SAAS00779839};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01300,
KW   ECO:0000256|SAAS:SAAS00779916};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01300,
KW   ECO:0000256|SAAS:SAAS00632312}.
FT   TRANSMEM     25     43       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
FT   TRANSMEM     63     81       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
FT   TRANSMEM     93    115       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
FT   TRANSMEM    166    184       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
FT   TRANSMEM    196    223       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
FT   TRANSMEM    235    258       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
FT   TRANSMEM    370    391       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01300}.
SQ   SEQUENCE   449 AA;  47092 MW;  D8CB014B1B9C6E83 CRC64;
     MAVTVPSPLT APQAPPAPKP LYKTLYFQVL VAVAIGILLG HFYPQLGAEM KPLGDAFIKL
     VKMIIAPVIF LTVVSGIAGM TNLEKVGRVG AKALIYFITF STLALIVGLV VANVLQPGHG
     LHIDPKSLDP KAVATYAGKA KEQSIVEFLM HIIPSTAVGA FAGGEILQVL FFSVLFGFGL
     AFMGDRGKPV LDLIKVTAEA IFGVVHIIMK VAPIGAFGAM AFTIGKYGVS SLANLAYLVF
     AFYLTSAIFV LVVLGPVARY NGFSVIKLVR YIKEELLLVL GTSSSESALP TLIDKMERAG
     CSRPVVGLVV PTGYSFNLDG TNIYMTMAAL FIAQATDTPL SLGEQALLLL VAMLSSKGAA
     GVTGSGFITL AATLAVVPSV PVVGMALILG IDRFMSECRA LTNFIGNAVA CIVVARWEGE
     VDEARLAAAL NGNPLPLAED VPAILQPAE
//

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