(data stored in ACNUC7421 zone)

SWISSPROT: B8IUE5_METNO

ID   B8IUE5_METNO            Unreviewed;      1009 AA.
AC   B8IUE5;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   30-AUG-2017, entry version 61.
DE   SubName: Full=Multi-sensor hybrid histidine kinase {ECO:0000313|EMBL:ACL55190.1};
DE            EC=2.7.13.3 {ECO:0000313|EMBL:ACL55190.1};
GN   OrderedLocusNames=Mnod_0144 {ECO:0000313|EMBL:ACL55190.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55190.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55190.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001349; ACL55190.1; -; Genomic_DNA.
DR   ProteinModelPortal; B8IUE5; -.
DR   STRING; 460265.Mnod_0144; -.
DR   EnsemblBacteria; ACL55190; ACL55190; Mnod_0144.
DR   KEGG; mno:Mnod_0144; -.
DR   eggNOG; ENOG4105BZU; Bacteria.
DR   eggNOG; ENOG410XNMH; LUCA.
DR   HOGENOM; HOG000032622; -.
DR   OMA; NRRAREW; -.
DR   OrthoDB; POG091H03T5; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 2.
DR   CDD; cd00156; REC; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF01627; Hpt; 1.
DR   Pfam; PF08447; PAS_3; 2.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 3.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF47226; SSF47226; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF55785; SSF55785; 3.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50894; HPT; 1.
DR   PROSITE; PS50113; PAC; 2.
DR   PROSITE; PS50112; PAS; 2.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
DR   PRODOM; B8IUE5.
DR   SWISS-2DPAGE; B8IUE5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Kinase {ECO:0000313|EMBL:ACL55190.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW   Transferase {ECO:0000313|EMBL:ACL55190.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     63     93       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      249    311       PAS (PER-ARNT-SIM). {ECO:0000259|PROSITE:
FT                                PS50112}.
FT   DOMAIN      323    374       PAC (PAS-associated C-terminal).
FT                                {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      375    445       PAS (PER-ARNT-SIM). {ECO:0000259|PROSITE:
FT                                PS50112}.
FT   DOMAIN      450    503       PAC (PAS-associated C-terminal).
FT                                {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      528    750       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   DOMAIN      770    887       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   DOMAIN      914   1009       HPt. {ECO:0000259|PROSITE:PS50894}.
FT   MOD_RES     819    819       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
FT   MOD_RES     954    954       Phosphohistidine. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00110}.
SQ   SEQUENCE   1009 AA;  107993 MW;  DCD325BCF03F58BC CRC64;
     MARAGMKAST ETPLDRIDRL RPSTRTPGTR RSACATLLIG VSGLTGWAGA AVAGESSALP
     AGWFGPALGI GLAAAVAAAA AAGAAAAAAI VLWRGRAQRA SGAGARVGTG PPAAAAAASG
     PESRVDAART AALLGKTLDC MDQGVILVGP DRTVQVANRR AREWLGLSEA FIASRPSYRE
     VRALARRSPH WGSLVADTPL QLSEDDPAAT HTVAERRNAE GTVLEIRTVR TEDGGLIQTL
     TDITERRSAE DRYRLLAENA TDLISLQSIR GGTKTYVSPS ARAVVGWEPE EFAQLTLAQQ
     LHPDDLARVK REAASLTPDA PRRTSEYRLR HKSGHYVWVE STLLLTKPGT PDEALIIASR
     DVTARRAADD ALRESEARHR LLAERTGDVI ARADLDGTLR YLSPSVEPVT GYAADALLGR
     SAMAHVHPQD RRTVLHRYAA LVAAGPGARA KFEYRVRHRH GHDVWLEVNP TVLYDEATGV
     PLGFVDVARD VTARKAVDAE LAAAREQAEA ARVHAELASQ AKTDFLASMS HEIRTPLSSV
     IGYTELLLDD PDLTEGQRLQ ASRIRSAGSA LLTVVDDILD FSKIEAGQVD LDLMPFALHG
     LIENAVAIVR QLAERKGLEI RVDIDPALPQ TLVGDQNRLR QILLNFLNNA LKFTRRGRVV
     LAVATAGSTD RGWPIRVSVT DTGIGIAPEQ QARLFKRFTQ VDGSIRREFG GTGLGLAISK
     KLIELMGGAI GVVSAPGEGS TFWFEVVLPE ASAAPAPAEA PLARPVRPAR ILLVEDLIVN
     QDLARAVLER AGHMVDVAND GLEAIAAVQA KDYDLVLMDV QMPGMDGVTA TRHIRALPQR
     VSLIPIIAMT ANVLPAQVSE FRAAGMNDHL GKPFRRDELQ AVIDRWIGEG TVAPHPGAGA
     AAAVDRRVYD DVVDLLGPDR LAHFLDELAR EIRDRLSDAR LAADDPQRLA RDAHSLVASA
     GTLGFSELSG LCKQLEEACQ SGASGDLLAA VRASRDRALD EIERLHTVA
//

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