(data stored in ACNUC7421 zone)

SWISSPROT: XERC_METNO

ID   XERC_METNO              Reviewed;         322 AA.
AC   B8I9N8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Tyrosine recombinase XerC {ECO:0000255|HAMAP-Rule:MF_01808};
GN   Name=xerC {ECO:0000255|HAMAP-Rule:MF_01808};
GN   OrderedLocusNames=Mnod_0247;
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. The XerC-XerD complex is essential to convert dimers of
CC       the bacterial chromosome into monomers to permit their segregation
CC       at cell division. It also contributes to the segregational
CC       stability of plasmids. {ECO:0000255|HAMAP-Rule:MF_01808}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD. {ECO:0000255|HAMAP-
CC       Rule:MF_01808}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01808}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01808}.
DR   EMBL; CP001349; ACL55291.1; -; Genomic_DNA.
DR   RefSeq; WP_015927004.1; NC_011894.1.
DR   ProteinModelPortal; B8I9N8; -.
DR   SMR; B8I9N8; -.
DR   STRING; 460265.Mnod_0247; -.
DR   EnsemblBacteria; ACL55291; ACL55291; Mnod_0247.
DR   KEGG; mno:Mnod_0247; -.
DR   eggNOG; ENOG4108IYT; Bacteria.
DR   eggNOG; COG0582; LUCA.
DR   HOGENOM; HOG000045294; -.
DR   KO; K03733; -.
DR   OMA; FASHMLE; -.
DR   OrthoDB; POG091H00PN; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_Lambda-type_N.
DR   InterPro; IPR023109; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF47823; SSF47823; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8I9N8.
DR   SWISS-2DPAGE; B8I9N8.
KW   Cell cycle; Cell division; Chromosome partition; Complete proteome;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding;
KW   Reference proteome.
FT   CHAIN         1    322       Tyrosine recombinase XerC.
FT                                /FTId=PRO_1000215954.
FT   ACT_SITE    170    170       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    195    195       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    263    263       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    266    266       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    289    289       {ECO:0000255|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    298    298       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_01808}.
SQ   SEQUENCE   322 AA;  34122 MW;  35BFAD20AB83FC7C CRC64;
     MLQTTPPDLL LGAPDLREAA AAWLAVLKTE RRFSENTVEA YGRDLRQFLA HLARSGAAPD
     IPALVALKPR DLRAFMAARR AEGVSGRSLM RALAALRSFA RHLDREGHGT VSALSAVRSP
     KVERRLPRPL PVAAAVAMAS PDIRAGEDRP DWVLARDAAV LALLYGAGLR IGEALGIRRK
     DAPVGDIDTL TILGKGQKTR MVPVIAPVQA AVADYLAVCP HPLPPDGPLF VGQKGGPLSP
     RIVQLAVASL RGALGLPDSA TPHALRHSFA THLLARQGDL RAIQDLLGHA SLATTQVYTK
     VDSARLLSAF DAAHPRAGRP GG
//

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