(data stored in ACNUC7421 zone)

SWISSPROT: B8I9P6_METNO

ID   B8I9P6_METNO            Unreviewed;       952 AA.
AC   B8I9P6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   SubName: Full=Formate dehydrogenase, alpha subunit {ECO:0000313|EMBL:ACL55299.1};
GN   OrderedLocusNames=Mnod_0255 {ECO:0000313|EMBL:ACL55299.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55299.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55299.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001349; ACL55299.1; -; Genomic_DNA.
DR   RefSeq; WP_015927012.1; NC_011894.1.
DR   ProteinModelPortal; B8I9P6; -.
DR   STRING; 460265.Mnod_0255; -.
DR   EnsemblBacteria; ACL55299; ACL55299; Mnod_0255.
DR   KEGG; mno:Mnod_0255; -.
DR   eggNOG; ENOG4108IEG; Bacteria.
DR   eggNOG; COG3383; LUCA.
DR   HOGENOM; HOG000031440; -.
DR   KO; K00123; -.
DR   OMA; TNTAECH; -.
DR   OrthoDB; POG091H037M; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR   GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR009010; Asp_de-COase-like_dom.
DR   InterPro; IPR012675; Beta-grasp_dom.
DR   InterPro; IPR006478; Formate_DH_asu.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR   InterPro; IPR019574; NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   Pfam; PF10588; NADH-G_4Fe-4S_3; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SMART; SM00929; NADH-G_4Fe-4S_3; 1.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   TIGRFAMs; TIGR01591; Fdh-alpha; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
DR   PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR   PROSITE; PS00932; MOLYBDOPTERIN_PROK_3; 1.
PE   4: Predicted;
DR   PRODOM; B8I9P6.
DR   SWISS-2DPAGE; B8I9P6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Iron {ECO:0000256|SAAS:SAAS00509295};
KW   Iron-sulfur {ECO:0000256|SAAS:SAAS00077451};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00509306};
KW   Molybdenum {ECO:0000256|SAAS:SAAS00648831};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00509324};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207}.
FT   DOMAIN       18     96       2Fe-2S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51085}.
FT   DOMAIN      163    194       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
FT   DOMAIN      205    234       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
FT   DOMAIN      241    297       4Fe-4S Mo/W bis-MGD-type.
FT                                {ECO:0000259|PROSITE:PS51669}.
SQ   SEQUENCE   952 AA;  103855 MW;  33EF0639242BC6D4 CRC64;
     MALIKEIDYG TPIRVAEKTV TLTIDGESVT VPAGTSVMAA AMTAGTQIPK LCATDSLEPF
     GSCRLCLVEI EGRRGTPASC TTPAEDGMVV HTQTDRLAKL RKGVMELYIS DHPLDCLTCA
     ANGDCELQDM AGAVGLREVR YEEGADHFKK SSDLYLPKDE SNPYFTYDPA KCIVCNRCVR
     ACEEVQGTFA LTIAGRGFDS RVAAGPTNFF ESECVSCGAC VQACPTATLQ EKSIIAHGQP
     EHSAVTTCAY CGVGCAFKAE MQGTRVVRMV PYKDGKANEG HSCVKGRFAY GYAAHKDRIT
     KPMIRKKITD PWREVSWEEA IAYAASEFKR IQDSFGRDAV GGITSSRCTN EEAYLVQKLV
     RAAFGNNNVD TCARVCHSPT GYGLKTTLGT SAGTQDFKSV DEADVILVVG ANPTDGHPVF
     GSRMKKRLRQ GAKLIVADPR RIDLVKSPHI KADYHLPLKP GSNVAFVNAM AHVIVTEGLV
     DEAYVRERCD LADFEVWARF VADERHAPEM VGPMIGVDPA DLRAAARLYA TGGAAAIYYG
     LGVTEHSQGS TMVMGLANLA MATGNIGKPG AGVNPLRGQN NVQGSCDMGS FPHELSGYRH
     VSDDATRETF ESLWGATLSA EPGLRITNML DEAVGGGFKG LYIQGEDIAQ SDPDTHHVTA
     GLRAMECIVI QDLFLNETAK YAHVFLPGAS FLEKDGTFTN AERRISRVRK VMPPLGGYAD
     WEGTMLLSNA LGYPMHYTHP SEIMDEIAQL TPSFAGVSYA RLDELGSIQW PCNAEAPEGT
     PMMHVDRFVR GLGKFMITEY VPTDERTTAK YPLILTTGRI LSQYNVGAQT RRTHNSRWHE
     EDVLEIHPFD AESRGIVDGD LVALESRSGD IALKARVTER MQPGIVYTTF HHAKTGANVI
     TTDYSDWATN CPEYKVTAVQ VRRTNRPSDW QARFYEEDVS LTRIAQRLDA AE
//

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