(data stored in ACNUC7421 zone)

SWISSPROT: COXX_METNO

ID   COXX_METNO              Reviewed;         317 AA.
AC   B8I9Q3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 53.
DE   RecName: Full=Protoheme IX farnesyltransferase {ECO:0000255|HAMAP-Rule:MF_00154};
DE            EC=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme B farnesyltransferase {ECO:0000255|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme O synthase {ECO:0000255|HAMAP-Rule:MF_00154};
GN   Name=ctaB {ECO:0000255|HAMAP-Rule:MF_00154};
GN   OrderedLocusNames=Mnod_0262;
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00154}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00154}.
DR   EMBL; CP001349; ACL55306.1; -; Genomic_DNA.
DR   RefSeq; WP_015927019.1; NC_011894.1.
DR   STRING; 460265.Mnod_0262; -.
DR   EnsemblBacteria; ACL55306; ACL55306; Mnod_0262.
DR   KEGG; mno:Mnod_0262; -.
DR   eggNOG; ENOG4105F1R; Bacteria.
DR   eggNOG; COG0109; LUCA.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; HRKEEYA; -.
DR   OrthoDB; POG091H05F2; -.
DR   UniPathway; UPA00834; UER00712.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:InterPro.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8I9Q3.
DR   SWISS-2DPAGE; B8I9Q3.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Heme biosynthesis; Membrane; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    317       Protoheme IX farnesyltransferase.
FT                                /FTId=PRO_1000199655.
FT   TRANSMEM     25     45       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM     54     74       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    117    137       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    167    189       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    244    264       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
FT   TRANSMEM    281    301       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00154}.
SQ   SEQUENCE   317 AA;  33253 MW;  E09454C0F9BBA111 CRC64;
     MTSLTNSLNP AQTLAPASNG DVADFFALLK PRVMALVVFT ALVGMTVSPS HVNPVIGAVS
     LLMIAVGAGA SGCLNMWWDA DIDAVMTRTR SRPIPAGRIR PEEALTFGLV LAVGSVLMLG
     LAANWLAAGL LAFTIVFYTV IYSMWLKRAT AQNIVIGGAA GALPPMIGQA VVTGSVGIEG
     IILFLIIFIW TPPHFWALAL VKSADYAKAG IPMMPNVAGP DSTRRQIVGY TLLLAPLGLA
     PVALGFGGLI YGLVALLGGL AMLVLSLQVH RRREGESADK AAMSLFGFSI LYLFLLFSAL
     LAEQGLGLMR PIPVLLG
//

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