(data stored in ACNUC7421 zone)

SWISSPROT: B8IB13_METNO

ID   B8IB13_METNO            Unreviewed;       324 AA.
AC   B8IB13;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   RecName: Full=4-hydroxybenzoate octaprenyltransferase {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS00711828};
DE            EC=2.5.1.- {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS00336940};
DE   AltName: Full=4-HB polyprenyltransferase {ECO:0000256|HAMAP-Rule:MF_01635};
GN   Name=ubiA {ECO:0000256|HAMAP-Rule:MF_01635};
GN   OrderedLocusNames=Mnod_0363 {ECO:0000313|EMBL:ACL55406.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55406.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55406.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC       with an all-trans polyprenyl group. Mediates the second step in
CC       the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis,
CC       which is the condensation of the polyisoprenoid side chain with
CC       PHB, generating the first membrane-bound Q intermediate 3-
CC       octaprenyl-4-hydroxybenzoate. {ECO:0000256|HAMAP-Rule:MF_01635,
CC       ECO:0000256|SAAS:SAAS00711820}.
CC   -!- CATALYTIC ACTIVITY: 4-hydroxybenzoate + farnesylfarnesylgeraniol =
CC       3-octaprenyl-4-hydroxybenzoate. {ECO:0000256|HAMAP-Rule:MF_01635,
CC       ECO:0000256|SAAS:SAAS00711817}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01635, ECO:0000256|SAAS:SAAS00377743};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS00188628}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01635, ECO:0000256|SAAS:SAAS00711827}; Multi-pass membrane
CC       protein {ECO:0000256|HAMAP-Rule:MF_01635,
CC       ECO:0000256|SAAS:SAAS00711827}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01635, ECO:0000256|SAAS:SAAS00534287}.
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DR   EMBL; CP001349; ACL55406.1; -; Genomic_DNA.
DR   STRING; 460265.Mnod_0363; -.
DR   EnsemblBacteria; ACL55406; ACL55406; Mnod_0363.
DR   KEGG; mno:Mnod_0363; -.
DR   eggNOG; ENOG4105C4G; Bacteria.
DR   eggNOG; COG0382; LUCA.
DR   HOGENOM; HOG000003697; -.
DR   KO; K03179; -.
DR   OMA; WTLGFDT; -.
DR   OrthoDB; POG091H03R0; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01635; UbiA; 1.
DR   InterPro; IPR031103; HB_octoprenylTrfase.
DR   InterPro; IPR006370; HB_polyprenyltransferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8IB13.
DR   SWISS-2DPAGE; B8IB13.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00711821};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00711823};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00711829};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00415574};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00415579, ECO:0000313|EMBL:ACL55406.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00415577};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00415562};
KW   Ubiquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_01635,
KW   ECO:0000256|SAAS:SAAS00414999}.
FT   TRANSMEM     50     71       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM     77    101       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    122    142       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    148    166       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    175    194       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    200    221       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    242    262       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    268    285       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
FT   TRANSMEM    306    323       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01635}.
SQ   SEQUENCE   324 AA;  34808 MW;  991CFB3FB7CF5AF5 CRC64;
     MRILPKATGR KATGGPDRPV ADAVSGHWVD RHAPASWRPY LRLARIERPI GWWLLLLPCW
     WSASLAAIAA GRVGPDLWHL GLFLIGAVAM RGAGSTYNDI ADRDLDARVE RTRLRPLPSG
     RLRVRHALAF LVAQALIGLA VLLQFNRFAV VVGLFSLAPV AIYPFMKRVM PVPQLVLGLA
     FAWGALMGWA ALIGRLDAPA LWLYAGAIAW VIGYDTIYAV QDIEDDEIAG IKSSARFFGS
     QVRGAVAACF VAAVGCIAIA LALAGAGLPG FLGLALFGAH LGWQVRRLDP RNGAAALRLF
     RSNRDAGLIL FAGLALDALW QGLA
//

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