(data stored in ACNUC7421 zone)

SWISSPROT: B8IC68_METNO

ID   B8IC68_METNO            Unreviewed;       597 AA.
AC   B8IC68;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   SubName: Full=Thiamine pyrophosphate protein TPP binding domain protein {ECO:0000313|EMBL:ACL55456.1};
GN   OrderedLocusNames=Mnod_0414 {ECO:0000313|EMBL:ACL55456.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55456.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55456.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP001349; ACL55456.1; -; Genomic_DNA.
DR   RefSeq; WP_015927167.1; NC_011894.1.
DR   ProteinModelPortal; B8IC68; -.
DR   STRING; 460265.Mnod_0414; -.
DR   EnsemblBacteria; ACL55456; ACL55456; Mnod_0414.
DR   KEGG; mno:Mnod_0414; -.
DR   eggNOG; COG0028; LUCA.
DR   HOGENOM; HOG000258444; -.
DR   KO; K00156; -.
DR   OMA; AANWYAR; -.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8IC68.
DR   SWISS-2DPAGE; B8IC68.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        4    173       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      199    328       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      389    544       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   597 AA;  64743 MW;  DC66D576E5FB9ED5 CRC64;
     MAETVGDFVC QRLSDWGVRT IFGYPGDGIN GLLGAMQRHD PPFAFIQVRH EEMAAFMACA
     YAKFTGELGV CLATSGPGAT HLITGLYDAR LDHMPVLAIV GQQARNALGG HYQQELDLTS
     AFKDVAGAFV QQASAPAQVR HLVDRAVRIA RAGRQVTALV LPNDLQDAPY EDPPRKHGTL
     QSGVGYSDPR VLPKDADLKQ AAAVLNAGER VAILVGAGAL HAADEVIAVA ERLQAGAAKA
     LLGKAALPDD LPWVTGSIGL LGTKPSWDLM TECDTLLMIG SGFPYAEFLP KPGQARGVQI
     DLKAEMLSLR YPMEVPLVGD SEETLRALLP LLNQKPTGGE WRNRIEEGVT AWWKEAGDRA
     MAKANPVNPQ RVTWELSPRL PDRAIITSDS GSCANWFARD LKIRRDMMCS LSGGLASMGA
     AVPYAIAAKV AHPDRPVIAL VGDGAMQMNN MAELITVAKY RHLWPNQTWI CCVFNNEDLN
     QVTWEQRVQA GNPKYEATQV IPNVPYHRFA ELIGLKGLYV DDPERVGTAW DEALASPVPV
     VLEVKTDPEV PPLPPHITLE QARNFMAMLW QGEPKEGHLL ADTARQVLSR VLPGEGG
//

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