(data stored in ACNUC7421 zone)

SWISSPROT: B8ICB6_METNO

ID   B8ICB6_METNO            Unreviewed;       293 AA.
AC   B8ICB6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   08-MAY-2019, entry version 62.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding {ECO:0000313|EMBL:ACL55504.1};
DE            EC=1.1.1.157 {ECO:0000313|EMBL:ACL55504.1};
GN   OrderedLocusNames=Mnod_0462 {ECO:0000313|EMBL:ACL55504.1};
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55504.1, ECO:0000313|Proteomes:UP000008207};
RN   [1] {ECO:0000313|EMBL:ACL55504.1, ECO:0000313|Proteomes:UP000008207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC   {ECO:0000313|Proteomes:UP000008207};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001349; ACL55504.1; -; Genomic_DNA.
DR   RefSeq; WP_015927215.1; NC_011894.1.
DR   STRING; 460265.Mnod_0462; -.
DR   EnsemblBacteria; ACL55504; ACL55504; Mnod_0462.
DR   KEGG; mno:Mnod_0462; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000141498; -.
DR   KO; K00074; -.
DR   OMA; MAHPMGP; -.
DR   OrthoDB; 862072at2; -.
DR   BioCyc; MNOD460265:GCZK-462-MONOMER; -.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
DR   PRODOM; B8ICB6.
DR   SWISS-2DPAGE; B8ICB6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008207};
KW   NAD {ECO:0000256|PIRSR:PIRSR000105-2};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00324627,
KW   ECO:0000313|EMBL:ACL55504.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008207}.
FT   DOMAIN        7    185       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      189    284       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      12     17       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      94     94       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      99     99       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     121    121       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     145    145       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     276    276       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   SITE        142    142       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   293 AA;  32160 MW;  6B21EA7E7B55E4AC CRC64;
     MGIEIKTVGI IGAGQMGSGI AHVCAVSGLD VRLNDRDPER LKNGLATVNG NLQRQVAKGT
     ITEEARRAAI ERIQPVESFD EFTPCDLVIE AATEDEAIKR NIFSALCPSL RPETMVATNT
     SSISITRLAA STDRPERFIG IHFMNPVPVM QLVELIRGIA TEDPTFESAR TFVNRLGKTV
     TVSEDFPAFI VNRILLPMIN EAIYTLYEGV GSVDSIDTAM RLGANHPMGP LQLADFIGLD
     TCLSIMQVLY EGLADSKYRP CPLLVKYVEA GWLGRKSKRG FYDYRGPEPV PTR
//

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