(data stored in ACNUC7421 zone)

SWISSPROT: KDSB_METNO

ID   KDSB_METNO              Reviewed;         247 AA.
AC   B8ICG5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   07-JUN-2017, entry version 57.
DE   RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase {ECO:0000255|HAMAP-Rule:MF_00057};
DE            EC=2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057};
DE   AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase {ECO:0000255|HAMAP-Rule:MF_00057};
DE            Short=CKS {ECO:0000255|HAMAP-Rule:MF_00057};
DE            Short=CMP-KDO synthase {ECO:0000255|HAMAP-Rule:MF_00057};
GN   Name=kdsB {ECO:0000255|HAMAP-Rule:MF_00057};
GN   OrderedLocusNames=Mnod_0512;
OS   Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=460265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Ivanova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium nodulans ORS
RT   2060.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Activates KDO (a required 8-carbon sugar) for
CC       incorporation into bacterial lipopolysaccharide in Gram-negative
CC       bacteria. {ECO:0000255|HAMAP-Rule:MF_00057}.
CC   -!- CATALYTIC ACTIVITY: CTP + 3-deoxy-D-manno-octulosonate =
CC       diphosphate + CMP-3-deoxy-D-manno-octulosonate.
CC       {ECO:0000255|HAMAP-Rule:MF_00057}.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-
CC       octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from
CC       3-deoxy-D-manno-octulosonate and CTP: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00057}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00057}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00057}.
CC   -!- SIMILARITY: Belongs to the KdsB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00057}.
DR   EMBL; CP001349; ACL55553.1; -; Genomic_DNA.
DR   RefSeq; WP_015927263.1; NC_011894.1.
DR   ProteinModelPortal; B8ICG5; -.
DR   SMR; B8ICG5; -.
DR   STRING; 460265.Mnod_0512; -.
DR   EnsemblBacteria; ACL55553; ACL55553; Mnod_0512.
DR   KEGG; mno:Mnod_0512; -.
DR   eggNOG; ENOG4105CET; Bacteria.
DR   eggNOG; COG1212; LUCA.
DR   HOGENOM; HOG000007602; -.
DR   KO; K00979; -.
DR   OMA; NSGTERC; -.
DR   OrthoDB; POG091H00UN; -.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00358; UER00476.
DR   Proteomes; UP000008207; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008690; F:3-deoxy-manno-octulosonate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0033468; P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02517; CMP-KDO-Synthetase; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   HAMAP; MF_00057; KdsB; 1.
DR   InterPro; IPR003329; Cytidylyl_trans.
DR   InterPro; IPR004528; KdsB.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF02348; CTP_transf_3; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR00466; kdsB; 1.
PE   3: Inferred from homology;
DR   PRODOM; B8ICG5.
DR   SWISS-2DPAGE; B8ICG5.
KW   Complete proteome; Cytoplasm; Lipopolysaccharide biosynthesis;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN         1    247       3-deoxy-manno-octulosonate
FT                                cytidylyltransferase.
FT                                /FTId=PRO_1000117804.
SQ   SEQUENCE   247 AA;  26558 MW;  DE7E83B8C386E891 CRC64;
     MSDPLILIPA RLGATRLPDK PLADICGEPM IVHVWRRAIA AGLGPVVVCT DAPTVVAAVE
     AVGGLAVLTR PDHPSGSDRL AEALGIIDPE GRHDVVVNLQ GDLPTIDPGI VAAAVTPLAD
     RAVDIATLCA VITRDEERTE PSVVKLVGSP ITPTRLRALY FTRATAPWGE GPLYHHIGLY
     AYRRRALERF VSLSPSVLER REKLEQLRAL EAGMRIDAVV VDDVPLGVDT PHDLDRARAV
     MAARRLN
//

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