(data stored in ACNUC8465 zone)

SWISSPROT: C1E1S3_MICCC

ID   C1E1S3_MICCC            Unreviewed;       227 AA.
AC   C1E1S3;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   10-APR-2019, entry version 35.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|RuleBase:RU364141};
DE   AltName: Full=Mediator complex subunit 4 {ECO:0000256|RuleBase:RU364141};
GN   Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN   ORFNames=MICPUN_56974 {ECO:0000313|EMBL:ACO61790.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC   Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO61790.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO61790.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364141}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364141}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000256|RuleBase:RU364141}.
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DR   EMBL; CP001324; ACO61790.1; -; Genomic_DNA.
DR   RefSeq; XP_002500532.1; XM_002500486.1.
DR   GeneID; 8241723; -.
DR   KEGG; mis:MICPUN_56974; -.
DR   HOGENOM; HOG000264300; -.
DR   InParanoid; C1E1S3; -.
DR   OMA; NLVEESW; -.
DR   OrthoDB; 1404352at2759; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019258; Mediator_Med4.
DR   PANTHER; PTHR13208; PTHR13208; 1.
DR   Pfam; PF10018; Med4; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E1S3.
DR   SWISS-2DPAGE; C1E1S3.
KW   Activator {ECO:0000256|RuleBase:RU364141};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Nucleus {ECO:0000256|RuleBase:RU364141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW   Transcription {ECO:0000256|RuleBase:RU364141};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364141}.
FT   COILED       90    117       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   227 AA;  24261 MW;  BC16AF0FD1D9FD09 CRC64;
     MATDEEVAWC AELRRAVTSL QDSIDAARSF DHVRLPADGP VSAADVVEYA RRISYTTFAP
     AGYQPGAPLH GIMPPAPQDE HFAASHLAAH AAQARQREEA RRAREKAAEE ARKAASRGEM
     PPIETVIKLL SAWKPGQPWP AGIPAPPPGW KPGDPLHLGA PKPKDDGGKG SVRVEPPARV
     VPAAVTAPPV KPAKPVMPKV PFVKIDLHSD SDEFEEVSAS DYSSDSD
//

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