(data stored in ACNUC8465 zone)

SWISSPROT: C1E202_MICCC

ID   C1E202_MICCC            Unreviewed;       551 AA.
AC   C1E202;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   10-APR-2019, entry version 37.
DE   RecName: Full=Patatin {ECO:0000256|RuleBase:RU361262};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361262};
GN   ORFNames=MICPUN_105298 {ECO:0000313|EMBL:ACO61834.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC   Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO61834.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO61834.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- FUNCTION: Lipolytic acyl hydrolase (LAH).
CC       {ECO:0000256|RuleBase:RU361262}.
CC   -!- DOMAIN: The nitrogen atoms of the two glycine residues in the GGXR
CC       motif define the oxyanion hole, and stabilize the oxyanion that
CC       forms during the nucleophilic attack by the catalytic serine
CC       during substrate cleavage. {ECO:0000256|RuleBase:RU361262}.
CC   -!- SIMILARITY: Belongs to the patatin family.
CC       {ECO:0000256|RuleBase:RU361262}.
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DR   EMBL; CP001324; ACO61834.1; -; Genomic_DNA.
DR   RefSeq; XP_002500576.1; XM_002500530.1.
DR   STRING; 296587.XP_002500576.1; -.
DR   GeneID; 8242185; -.
DR   KEGG; mis:MICPUN_105298; -.
DR   HOGENOM; HOG000264952; -.
DR   InParanoid; C1E202; -.
DR   OMA; SGWLFVY; -.
DR   OrthoDB; 1290525at2759; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR033562; PLPL.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR12406; PTHR12406; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E202.
DR   SWISS-2DPAGE; C1E202.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Hydrolase {ECO:0000256|RuleBase:RU361262};
KW   Lipid degradation {ECO:0000256|RuleBase:RU361262};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU361262};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT   DOMAIN       49    202       PNPLA. {ECO:0000259|Pfam:PF01734}.
SQ   SEQUENCE   551 AA;  60989 MW;  6CFF89CB19BA8045 CRC64;
     MPPVLRPRTP KKGDAPRVKT PGSARPVRRE FRNGARAGTG AEDQKWSFAL SSSGWLFVYY
     IGVVKALASR GFHRNSKIYG TSGGALTGCL LFLDIDLDAL AEYAYICAAE ARASIRGAFK
     LRDYCRGAIT QFCTANAHEI LQGRFEVSIT RIFPWYKNLR VNNFPTYDFL IQSLMCSACI
     TPLAGFPMWL KGHGLCFDGG VSDFQILKGL ARNGTFCKLH CRKTNPKDLV VVCPFYSSRA
     NIRPSKYVPI WWAFYPPPPY KLKELFELGQ KDAHAWCDKQ EDAGSSPEKD DSPRATSSEG
     SRSSDEDDDM EWEWQRKEKA QARGTSDAKD LSRESSVTAD DQDMEPPTSP TATNRGFTEW
     AAECQEWASL SAEAAARRAM SAARAAANKA EAFVHHEAEV VHTYASGKFC QAQAAAEAMR
     RVASKSNLPE IDLIADLDDD DPEEEIPRGR FQAHRLLLKS LACMVIYLEL VAQTLLNVCG
     AGAALLLPGV RSGKLREKVF ECCRPLPRVL LQPVPGVRKV AKIDGKTAKA LGNISVAYRV
     LCYLVHMEVH C
//

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