(data stored in ACNUC8465 zone)

SWISSPROT: C1E0P8_MICCC

ID   C1E0P8_MICCC            Unreviewed;       332 AA.
AC   C1E0P8;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   30-AUG-2017, entry version 46.
DE   RecName: Full=Malate dehydrogenase {ECO:0000256|RuleBase:RU003405};
DE            EC=1.1.1.37 {ECO:0000256|RuleBase:RU003405};
GN   ORFNames=MICPUN_99233 {ECO:0000313|EMBL:ACO62039.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO62039.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO62039.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.
CC       {ECO:0000256|RuleBase:RU003405}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily.
CC       {ECO:0000256|RuleBase:RU003369}.
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DR   EMBL; CP001324; ACO62039.1; -; Genomic_DNA.
DR   RefSeq; XP_002500781.1; XM_002500735.1.
DR   ProteinModelPortal; C1E0P8; -.
DR   GeneID; 8241529; -.
DR   KEGG; mis:MICPUN_99233; -.
DR   HOGENOM; HOG000220953; -.
DR   InParanoid; C1E0P8; -.
DR   KO; K00025; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   CDD; cd01336; MDH_cytoplasmic_cytosolic; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR001252; Malate_DH_AS.
DR   InterPro; IPR011274; Malate_DH_NAD-dep_euk.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
DR   TIGRFAMs; TIGR01759; MalateDH-SF1; 1.
DR   TIGRFAMs; TIGR01758; MDH_euk_cyt; 1.
DR   PROSITE; PS00068; MDH; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E0P8.
DR   SWISS-2DPAGE; C1E0P8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   NAD {ECO:0000256|RuleBase:RU003405};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003405};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU003405}.
FT   DOMAIN        6    152       Ldh_1_N. {ECO:0000259|Pfam:PF00056}.
FT   DOMAIN      156    327       Ldh_1_C. {ECO:0000259|Pfam:PF02866}.
FT   ACT_SITE    187    187       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000102-1}.
SQ   SEQUENCE   332 AA;  34928 MW;  6D8D8D7AC6DD7DA4 CRC64;
     MVSPVTVMIT GAAGQIGYAL APQVCRGAML GPDTPIILHL LDIAPAETAL KGVAMELVDA
     AYPLVKKIVA TVNLEEACKG VDVAVMVGGF PRGPGMERKD VMAKNVAIYK GQASALQEHA
     SPDVKVVVVA NPANTNALIL SNYAPKIPKE NVTCLTRLDH NRALGQVSER TGVPVSDVKN
     CIIWGNHSST QYPDVNHATA GGKSVRELVN DDEYLNGEFV TTVQQRGAAI IAARKFSSAL
     SAASSVCDHV RDWVHGTPEG TWTSMGVISP GGDAGYGVEA GLMYSFPVTC AGGKWSIVQG
     LAIDDRSRSL MDATAAELKE EKTMAEELIA AM
//

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