(data stored in ACNUC8465 zone)

SWISSPROT: C1E1F3_MICCC

ID   C1E1F3_MICCC            Unreviewed;       301 AA.
AC   C1E1F3;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 33.
DE   RecName: Full=DNA-(apurinic or apyrimidinic site) lyase {ECO:0000256|RuleBase:RU362131};
DE            EC=4.2.99.18 {ECO:0000256|RuleBase:RU362131};
GN   ORFNames=MICPUN_79714 {ECO:0000313|EMBL:ACO62160.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO62160.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO62160.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU362131};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU362131};
CC       Note=Probably binds two magnesium or manganese ions per subunit.
CC       {ECO:0000256|RuleBase:RU362131};
CC   -!- SIMILARITY: Belongs to the DNA repair enzymes AP/ExoA family.
CC       {ECO:0000256|RuleBase:RU362131}.
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DR   EMBL; CP001324; ACO62160.1; -; Genomic_DNA.
DR   RefSeq; XP_002500902.1; XM_002500856.1.
DR   GeneID; 8241662; -.
DR   KEGG; mis:MICPUN_79714; -.
DR   HOGENOM; HOG000034586; -.
DR   InParanoid; C1E1F3; -.
DR   KO; K01142; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR004808; AP_endonuc_1.
DR   InterPro; IPR020847; AP_endonuclease_F1_BS.
DR   InterPro; IPR020848; AP_endonuclease_F1_CS.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   PANTHER; PTHR22748; PTHR22748; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   TIGRFAMs; TIGR00633; xth; 1.
DR   PROSITE; PS00726; AP_NUCLEASE_F1_1; 1.
DR   PROSITE; PS00728; AP_NUCLEASE_F1_3; 1.
DR   PROSITE; PS51435; AP_NUCLEASE_F1_4; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E1F3.
DR   SWISS-2DPAGE; C1E1F3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   DNA damage {ECO:0000256|RuleBase:RU362131};
KW   DNA repair {ECO:0000256|RuleBase:RU362131};
KW   Lyase {ECO:0000256|RuleBase:RU362131};
KW   Magnesium {ECO:0000256|RuleBase:RU362131};
KW   Metal-binding {ECO:0000256|RuleBase:RU362131};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009}.
FT   DOMAIN       29    290       Endo/exonuclease/phosphatase.
FT                                {ECO:0000259|Pfam:PF03372}.
SQ   SEQUENCE   301 AA;  33468 MW;  075AEEF7C3BD5FBB CRC64;
     MRWDVTDPPL PPRAPRLDRA LHPSKLTVLS WNVNSIRALL DKDPDILDEV AASEDADVVL
     LQETKLQEKH VPEMDARVLA KYPYRTWNCS TSRLGYSGTA MFLRLEPTRA PWHDPFEMDE
     FEGEGRVVCA ELPNVFVVGA YCPNSGEGLA RLRARTKEWD PRMSAYLSSL QASAGGKPVV
     YCGDLNVANE PIDLWGNHAA NSLASGYTPE ERDSFKRLLL GPIRDGGAGL VDTFREAHGT
     DAKAFTYFSY RAGARPRNRG WRIDYALVSE SLRGEVHDAF IRGDVGGSDH CPIGVVVKLR
     E
//

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