(data stored in ACNUC8465 zone)

SWISSPROT: C1E1P5_MICCC

ID   C1E1P5_MICCC            Unreviewed;       539 AA.
AC   C1E1P5;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 43.
DE   RecName: Full=Pyruvate kinase {ECO:0000256|RuleBase:RU000504};
DE            EC=2.7.1.40 {ECO:0000256|RuleBase:RU000504};
GN   ORFNames=MICPUN_56945 {ECO:0000313|EMBL:ACO62203.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO62203.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO62203.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + pyruvate = ADP + phosphoenolpyruvate.
CC       {ECO:0000256|RuleBase:RU000504}.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 5/5.
CC       {ECO:0000256|RuleBase:RU000504}.
CC   -!- SIMILARITY: Belongs to the pyruvate kinase family.
CC       {ECO:0000256|RuleBase:RU000504}.
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DR   EMBL; CP001324; ACO62203.1; -; Genomic_DNA.
DR   RefSeq; XP_002500945.1; XM_002500899.1.
DR   ProteinModelPortal; C1E1P5; -.
DR   GeneID; 8241711; -.
DR   KEGG; mis:MICPUN_56945; -.
DR   HOGENOM; HOG000021559; -.
DR   InParanoid; C1E1P5; -.
DR   KO; K00873; -.
DR   UniPathway; UPA00109; UER00188.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR   GO; GO:0004743; F:pyruvate kinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1380.20; -; 1.
DR   InterPro; IPR001697; Pyr_Knase.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR011037; Pyrv_Knase-like_insert_dom.
DR   InterPro; IPR018209; Pyrv_Knase_AS.
DR   InterPro; IPR015793; Pyrv_Knase_brl.
DR   InterPro; IPR015795; Pyrv_Knase_C.
DR   PANTHER; PTHR11817; PTHR11817; 1.
DR   Pfam; PF00224; PK; 1.
DR   Pfam; PF02887; PK_C; 1.
DR   PRINTS; PR01050; PYRUVTKNASE.
DR   SUPFAM; SSF50800; SSF50800; 1.
DR   SUPFAM; SSF51621; SSF51621; 2.
DR   SUPFAM; SSF52935; SSF52935; 1.
DR   TIGRFAMs; TIGR01064; pyruv_kin; 1.
DR   PROSITE; PS00110; PYRUVATE_KINASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E1P5.
DR   SWISS-2DPAGE; C1E1P5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Glycolysis {ECO:0000256|RuleBase:RU000504};
KW   Kinase {ECO:0000256|RuleBase:RU000504, ECO:0000313|EMBL:ACO62203.1};
KW   Magnesium {ECO:0000256|RuleBase:RU000504};
KW   Pyruvate {ECO:0000313|EMBL:ACO62203.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW   Transferase {ECO:0000256|RuleBase:RU000504}.
FT   DOMAIN       52    394       PK. {ECO:0000259|Pfam:PF00224}.
FT   DOMAIN      409    536       PK_C. {ECO:0000259|Pfam:PF02887}.
SQ   SEQUENCE   539 AA;  57839 MW;  E32655941C02266F CRC64;
     MANIQVDDIL AGTPAVQCKT KVRAPSAPTT RDPPARFLTR LANYGIPLAP EQIVCTLGPK
     SAELSIMEDL LRAGMSVARF NFSHGSHEYH QGTLNTLRQA MLNTRLMCAV LLDTKGPEIR
     TGMLKGGKPV LMEAGREVTI HTDYTLHGDE HNIAMSYKKL PNDVAPGAEI LIGDGSIVMV
     VLSCHPENGT VRCRCANTAM LGERKNVNLP GVVVDLPTIT EKDRDDILGW GVPNGIDFIA
     ASFVRKGSDV RYIREVLGEE GKSIKIISKV ENQEGLVNFD DILEESDGVM VARGDLGMEI
     PTEKIFLAQK LMIEKCNAAG KPVVTATQML ESMVKNPRPT RAEATDVANA VLDGTDCVML
     SGETAAGAFP VDAVRVMSKI CREAEVSIDH YQLFKSILAQ VPIPMQPLES LASSAVRTAQ
     KVRAALIVVL THGGSTARLV AKYRPAVPVL TVFVPTLTTD SLTWQCSGES PARQANLTRG
     LIPLLAEGSA RATDTDTTDE ILHAAIDHAK AAGYCASGEC IVALHRIGNA SVIKIVNIP
//

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