(data stored in ACNUC7421 zone)

SWISSPROT: C3MFR6_SINFN

ID   C3MFR6_SINFN            Unreviewed;       737 AA.
AC   C3MFR6;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   07-JUN-2017, entry version 61.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ACP23967.1};
GN   Name=fadB {ECO:0000313|EMBL:ACP23967.1};
GN   OrderedLocusNames=NGR_c01670 {ECO:0000313|EMBL:ACP23967.1};
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394 {ECO:0000313|EMBL:ACP23967.1, ECO:0000313|Proteomes:UP000001054};
RN   [1] {ECO:0000313|EMBL:ACP23967.1, ECO:0000313|Proteomes:UP000001054}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234 {ECO:0000313|Proteomes:UP000001054};
RX   PubMed=19376903; DOI=10.1128/AEM.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of
RT   secretion systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
CC       + NADH. {ECO:0000256|SAAS:SAAS00379695}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00649747}.
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DR   EMBL; CP001389; ACP23967.1; -; Genomic_DNA.
DR   RefSeq; WP_012706752.1; NC_012587.1.
DR   RefSeq; YP_002824720.1; NC_012587.1.
DR   ProteinModelPortal; C3MFR6; -.
DR   STRING; 394.NGR_c01670; -.
DR   EnsemblBacteria; ACP23967; ACP23967; NGR_c01670.
DR   GeneID; 7790745; -.
DR   KEGG; rhi:NGR_c01670; -.
DR   PATRIC; fig|394.7.peg.2962; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000261345; -.
DR   KO; K01782; -.
DR   OMA; PFRYMDT; -.
DR   OrthoDB; POG091H0NDD; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000001054; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR013328; 6PGD_dom_2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom.
DR   InterPro; IPR001753; Crotonase_core_superfam.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
DR   PRODOM; C3MFR6.
DR   SWISS-2DPAGE; C3MFR6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001054};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00456821};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00456809};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00656508};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001054}.
FT   DOMAIN      328    507       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      509    606       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   737 AA;  79704 MW;  04A5E8C25505724F CRC64;
     MSYTNFKIET DADGIALVTW DMPDKSMNVF TEEVMDELDA IVDQTTADAA VKGVVFTSGK
     SSFSGGADLS MIKSMFTLQA EERKKDPANA AQKLFNLVGR MTGLFRKLET SGKPWVSAIN
     GTCMGGAFEL SLACHGRVAS NSKSVKIALP EVKVGIFPGA GGTQRVPRLT NTQDALQMMT
     TGSSLTAARA KAMGLVHEVV EPEKLVEAAK AMIKNGLKAV QPWDEKGFKL PGGGVWTPAS
     AQLWPAASGI LRRETYGNYP GAIAILKCVY EGLQVPFDTG LKIEQRYFTE ILQTTEAFSM
     IRSLFVSMQE LGKGARRPAG VPKTEFKTVG VVGAGFMGAS IAYVTAAAGI PVTLIDRDME
     ASEKGKAHSE GLVKDAIGKG RLTKEEGEAL LSRITPSADY GDLKDAGLVV EAVFEDRQVK
     KDVIEKVEAV IAPDAIFASN TSTLPITGLA RNSKRPEQFI GVHFFSPVEK MMLTEVIVGK
     ETGDKALATA LDYVAAIKKT PIVVNDTRGF YVNRCVFRYI HEAYDMLIEG VPPAMIENAA
     KMAGMPVGPL SLNDEVAIDL SQKILKATVA DLGEKAVDPR HMELVNKMVD ELDRRGRKNG
     KGFYEYPAKP AKKYLWPGLK ELYSQKPADK VDVEVVKQRF LATIALEAAR TIEEGIVTDP
     READVGSILG FGFAPYTGGT LSYIDGMGIK AFVAMCNKLA KAYGDHFEPT PLLKEMAEKG
     ETFYGRFDPY GQAQKAA
//

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