(data stored in ACNUC7421 zone)

SWISSPROT: MSCL_SINFN

ID   MSCL_SINFN              Reviewed;         142 AA.
AC   C3MFT5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   RecName: Full=Large-conductance mechanosensitive channel {ECO:0000255|HAMAP-Rule:MF_00115};
GN   Name=mscL {ECO:0000255|HAMAP-Rule:MF_00115};
GN   OrderedLocusNames=NGR_c01860;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/AEM.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of
RT   secretion systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Channel that opens in response to stretch forces in the
CC       membrane lipid bilayer. May participate in the regulation of
CC       osmotic pressure changes within the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_00115}.
CC   -!- SUBUNIT: Homopentamer. {ECO:0000255|HAMAP-Rule:MF_00115}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00115}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00115}.
CC   -!- SIMILARITY: Belongs to the MscL family. {ECO:0000255|HAMAP-
CC       Rule:MF_00115}.
DR   EMBL; CP001389; ACP23986.1; -; Genomic_DNA.
DR   RefSeq; WP_012706771.1; NC_012587.1.
DR   RefSeq; YP_002824739.1; NC_012587.1.
DR   STRING; 394.NGR_c01860; -.
DR   PRIDE; C3MFT5; -.
DR   EnsemblBacteria; ACP23986; ACP23986; NGR_c01860.
DR   GeneID; 7790764; -.
DR   KEGG; rhi:NGR_c01860; -.
DR   PATRIC; fig|394.7.peg.2981; -.
DR   eggNOG; ENOG4105M2E; Bacteria.
DR   eggNOG; COG1970; LUCA.
DR   HOGENOM; HOG000226782; -.
DR   KO; K03282; -.
DR   OMA; YGSFIQT; -.
DR   OrthoDB; 1863650at2; -.
DR   Proteomes; UP000001054; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.1200.120; -; 1.
DR   HAMAP; MF_00115; MscL; 1.
DR   InterPro; IPR036019; Gated_MS_channel.
DR   InterPro; IPR019823; Mechanosensitive_channel_CS.
DR   InterPro; IPR001185; MS_channel.
DR   InterPro; IPR037673; MSC/AndL.
DR   PANTHER; PTHR30266; PTHR30266; 1.
DR   Pfam; PF01741; MscL; 1.
DR   PRINTS; PR01264; MECHCHANNEL.
DR   SUPFAM; SSF81330; SSF81330; 1.
DR   TIGRFAMs; TIGR00220; mscL; 1.
DR   PROSITE; PS01327; MSCL; 1.
PE   3: Inferred from homology;
DR   PRODOM; C3MFT5.
DR   SWISS-2DPAGE; C3MFT5.
KW   Cell inner membrane; Cell membrane; Complete proteome; Ion channel;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    142       Large-conductance mechanosensitive
FT                                channel.
FT                                /FTId=PRO_1000191383.
FT   TRANSMEM     14     34       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00115}.
FT   TRANSMEM     38     58       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00115}.
FT   TRANSMEM     82    102       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_00115}.
SQ   SEQUENCE   142 AA;  15393 MW;  8E3A934B7418F4DC CRC64;
     MLNEFKEFIA RGNVMDLAVG VIIGAAFTKI VTSVVDDLVM PIVGAITGGG FDFSNYFLPL
     SANVTAPTLA AARQQGAVFA YGSFITVLIN FMILAWIIFL LVKAVNRIRA SVEREKAPEP
     AAPPPEDVRL LSEIRDILKQ RA
//

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