(data stored in ACNUC7421 zone)

SWISSPROT: PNCB_SINFN

ID   PNCB_SINFN              Reviewed;         434 AA.
AC   C3MFW1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   07-JUN-2017, entry version 51.
DE   RecName: Full=Nicotinate phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_00570};
DE            Short=NAPRTase {ECO:0000255|HAMAP-Rule:MF_00570};
DE            EC=6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570};
GN   Name=pncB {ECO:0000255|HAMAP-Rule:MF_00570};
GN   OrderedLocusNames=NGR_c02120;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/AEM.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of
RT   secretion systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Catalyzes the synthesis of beta-nicotinate D-
CC       ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate
CC       at the expense of ATP. {ECO:0000255|HAMAP-Rule:MF_00570}.
CC   -!- CATALYTIC ACTIVITY: Nicotinate + 5-phospho-alpha-D-ribose 1-
CC       diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide +
CC       diphosphate + ADP + phosphate. {ECO:0000255|HAMAP-Rule:MF_00570}.
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-
CC       ribonucleotide from nicotinate: step 1/1. {ECO:0000255|HAMAP-
CC       Rule:MF_00570}.
CC   -!- SIMILARITY: Belongs to the NAPRTase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00570}.
DR   EMBL; CP001389; ACP24012.1; -; Genomic_DNA.
DR   RefSeq; WP_012706797.1; NC_012587.1.
DR   RefSeq; YP_002824765.1; NC_012587.1.
DR   ProteinModelPortal; C3MFW1; -.
DR   SMR; C3MFW1; -.
DR   STRING; 394.NGR_c02120; -.
DR   EnsemblBacteria; ACP24012; ACP24012; NGR_c02120.
DR   GeneID; 7790790; -.
DR   KEGG; rhi:NGR_c02120; -.
DR   PATRIC; fig|394.7.peg.3012; -.
DR   eggNOG; ENOG4107RH7; Bacteria.
DR   eggNOG; COG1488; LUCA.
DR   HOGENOM; HOG000284929; -.
DR   KO; K00763; -.
DR   OMA; KLTMQCA; -.
DR   OrthoDB; POG091H0197; -.
DR   UniPathway; UPA00253; UER00457.
DR   Proteomes; UP000001054; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:InterPro.
DR   GO; GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019357; P:nicotinate nucleotide biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00570; NAPRTase; 1.
DR   InterPro; IPR006406; Nic_PRibTrfase.
DR   InterPro; IPR007229; Nic_PRibTrfase-Fam.
DR   InterPro; IPR002638; Quinolinate_PRibosylTrfase_C.
DR   PANTHER; PTHR11098; PTHR11098; 1.
DR   Pfam; PF04095; NAPRTase; 1.
DR   PIRSF; PIRSF000484; NAPRT; 1.
DR   SUPFAM; SSF51690; SSF51690; 1.
DR   TIGRFAMs; TIGR01514; NAPRTase; 1.
PE   3: Inferred from homology;
DR   PRODOM; C3MFW1.
DR   SWISS-2DPAGE; C3MFW1.
KW   Complete proteome; Ligase; Pyridine nucleotide biosynthesis;
KW   Reference proteome; Transferase.
FT   CHAIN         1    434       Nicotinate phosphoribosyltransferase.
FT                                /FTId=PRO_1000191531.
SQ   SEQUENCE   434 AA;  49809 MW;  462B82671F27648C CRC64;
     MPKTDIARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWQ LYPDVDATFS LINRTKTVRL
     AEEIDEQELR DQLDHARTLR FSKKEMIWLA GNTFYGRKQI FSPEFLSWLA RFRLPEYELS
     RRDGQFELTF RGRWVETTMW EIPALAIINE LRSRAAMKGL GPFTLDVLYA RAKAKMWSKV
     EQLRQYPNLR ISDFGTRRRH SFLWQRWCVE ALKEGIGASF SGSSNVLLAM DNDLEALGTN
     AHELPMVAAA LARNDKELAA APYKVLQDWN QLYGGNLLIV LPDSFGTAAF LRNAPDWVAD
     WTGFRPDSAP PVEGGEKILA WWKKKGRDPR DKLLIFSDGL DVDTIIKTYR HFEGRVRMSF
     GWGTNLTNDF AGCAPTEIGG LNPISIVCKV SEANGRPAVK LSDNPRKATG DPAEVERYLK
     FFGTEDFVEQ TVRV
//

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