(data stored in ACNUC7421 zone)

SWISSPROT: C3MGT2_SINFN

ID   C3MGT2_SINFN            Unreviewed;       507 AA.
AC   C3MGT2;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   07-JUN-2017, entry version 64.
DE   RecName: Full=Histidine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00127};
DE            EC=6.1.1.21 {ECO:0000256|HAMAP-Rule:MF_00127};
DE   AltName: Full=Histidyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00127};
DE            Short=HisRS {ECO:0000256|HAMAP-Rule:MF_00127};
GN   Name=hisS {ECO:0000256|HAMAP-Rule:MF_00127};
GN   OrderedLocusNames=NGR_c04010 {ECO:0000313|EMBL:ACP24197.1};
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394 {ECO:0000313|EMBL:ACP24197.1, ECO:0000313|Proteomes:UP000001054};
RN   [1] {ECO:0000313|EMBL:ACP24197.1, ECO:0000313|Proteomes:UP000001054}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234 {ECO:0000313|Proteomes:UP000001054};
RX   PubMed=19376903; DOI=10.1128/AEM.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of
RT   secretion systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP +
CC       diphosphate + L-histidyl-tRNA(His). {ECO:0000256|HAMAP-
CC       Rule:MF_00127, ECO:0000256|SAAS:SAAS00359674}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00127,
CC       ECO:0000256|SAAS:SAAS00742603}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00127,
CC       ECO:0000256|SAAS:SAAS00808017}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. {ECO:0000256|HAMAP-Rule:MF_00127,
CC       ECO:0000256|SAAS:SAAS00676298}.
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DR   EMBL; CP001389; ACP24197.1; -; Genomic_DNA.
DR   RefSeq; WP_012706982.1; NC_012587.1.
DR   RefSeq; YP_002824950.1; NC_012587.1.
DR   STRING; 394.NGR_c04010; -.
DR   EnsemblBacteria; ACP24197; ACP24197; NGR_c04010.
DR   GeneID; 7791627; -.
DR   KEGG; rhi:NGR_c04010; -.
DR   PATRIC; fig|394.7.peg.3207; -.
DR   eggNOG; ENOG4105CUT; Bacteria.
DR   eggNOG; COG0124; LUCA.
DR   HOGENOM; HOG000018071; -.
DR   KO; K01892; -.
DR   OMA; CDFDFIG; -.
DR   OrthoDB; POG091H021E; -.
DR   Proteomes; UP000001054; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP.
DR   CDD; cd00859; HisRS_anticodon; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00127; His_tRNA_synth; 1.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR015807; His-tRNA-ligase.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR033656; HisRS_anticodon.
DR   PANTHER; PTHR11476; PTHR11476; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   SUPFAM; SSF52954; SSF52954; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
DR   PRODOM; C3MGT2.
DR   SWISS-2DPAGE; C3MGT2.
KW   Aminoacyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00127,
KW   ECO:0000256|SAAS:SAAS00502864, ECO:0000313|EMBL:ACP24197.1};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00127,
KW   ECO:0000256|SAAS:SAAS00502908};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001054};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00127,
KW   ECO:0000256|SAAS:SAAS00808019};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00127,
KW   ECO:0000256|SAAS:SAAS00502874, ECO:0000313|EMBL:ACP24197.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00127,
KW   ECO:0000256|SAAS:SAAS00502847};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00127,
KW   ECO:0000256|SAAS:SAAS00502923};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001054}.
FT   DOMAIN       35    384       AA_TRNA_LIGASE_II. {ECO:0000259|PROSITE:
FT                                PS50862}.
SQ   SEQUENCE   507 AA;  55860 MW;  6CE16E09920ED7BF CRC64;
     MPSMNDKPKK PQKLKARLPR GFVDRSAADI RAVDEMIAKI REVYERYGFD PVETPLFEYT
     DALGKFLPDS DRPNEGVFSL TDDDEQWMSL RYDLTAPLAR HVAENFNEIQ LPHRTYRAGY
     VFRNEKPGPG RFRQFMQFDA DTVGAAGVQA DAEMCMMMAD TMEALGIARG DYVIRVNNRK
     VLDGVLEAIG LGGGDQANAR LTVLRAIDKL DKFGPEGVRL LLGEGRKDES GDFTKGAGLN
     EEQIRKILFF VGISDYAKSA GELAELVAGT GKGTEGVEEL NTIRSLVLSA GYEADRIKID
     PSVVRGLEYY TGPVFEAELQ FSVTNEKGEK VVFGSVGGGG RYDGLVSRFM GQPVPATGFS
     IGVSRLMTAL KNLGKLGVEE VVAPVVVCVM DRDIDSMGRY QRFVQQLRHA GIRAEMYQGN
     KKNFGDQLKY ADRRGSPIAI IQGGDERASG IVQIKDLIEG KRLSGEIEDN VAWREARVAQ
     VSVPEGDLVA KVREILAEQA EDRKRAG
//

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