(data stored in ACNUC7421 zone)

SWISSPROT: HISZ_SINFN

ID   HISZ_SINFN              Reviewed;         379 AA.
AC   C3MGT3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   30-AUG-2017, entry version 48.
DE   RecName: Full=ATP phosphoribosyltransferase regulatory subunit {ECO:0000255|HAMAP-Rule:MF_00125};
GN   Name=hisZ {ECO:0000255|HAMAP-Rule:MF_00125};
GN   OrderedLocusNames=NGR_c04020;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/AEM.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of
RT   secretion systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Required for the first step of histidine biosynthesis.
CC       May allow the feedback regulation of ATP phosphoribosyltransferase
CC       activity by histidine. {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
CC       {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00125}.
CC   -!- MISCELLANEOUS: This function is generally fulfilled by the C-
CC       terminal part of HisG, which is missing in some bacteria such as
CC       this one.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. HisZ subfamily. {ECO:0000255|HAMAP-Rule:MF_00125}.
DR   EMBL; CP001389; ACP24198.1; -; Genomic_DNA.
DR   RefSeq; WP_012706983.1; NC_012587.1.
DR   RefSeq; YP_002824951.1; NC_012587.1.
DR   STRING; 394.NGR_c04020; -.
DR   EnsemblBacteria; ACP24198; ACP24198; NGR_c04020.
DR   GeneID; 7791628; -.
DR   KEGG; rhi:NGR_c04020; -.
DR   PATRIC; fig|394.7.peg.3208; -.
DR   eggNOG; ENOG4105P5X; Bacteria.
DR   eggNOG; COG3705; LUCA.
DR   HOGENOM; HOG000141880; -.
DR   KO; K02502; -.
DR   OMA; YYTGFEF; -.
DR   OrthoDB; POG091H0GG3; -.
DR   UniPathway; UPA00031; UER00006.
DR   Proteomes; UP000001054; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00125; HisZ; 1.
DR   InterPro; IPR004516; HisRS/HisZ.
DR   InterPro; IPR004517; HisZ.
DR   PANTHER; PTHR43707; PTHR43707; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
PE   3: Inferred from homology;
DR   PRODOM; C3MGT3.
DR   SWISS-2DPAGE; C3MGT3.
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Reference proteome.
FT   CHAIN         1    379       ATP phosphoribosyltransferase regulatory
FT                                subunit.
FT                                /FTId=PRO_1000122674.
SQ   SEQUENCE   379 AA;  41472 MW;  AA310D928FCEC572 CRC64;
     MPLINLPAFA GDLLADFERL KTLRVDTPVI QPAEPFLDMA GEDLRRRIFM TQSETGDSLC
     LRPEFTIPVC LRHIETATGT PQRYAYLGEV FRQRREGSSE FYQAGIEDLG DTDTAGADAR
     AIGDAMRVLS NRLANRRLKV TLGDQSVFEA VIAACGLPGG WQKRLIHAFG DPKQLQKLLG
     ELADPKSPGV FGHEVERLAI LGILDDEERL VAHLAETMEA TGYSTNASRS PRDIARRLKE
     KMELATTRLD RAALAVMREF LAFDLPLSEA PAALHAFAKK SRLKIDDALS LFDARVAAIA
     KVGAESDLIR YRAAFGRPLD YYTGLVFEIE AEGAPAVLAG GGRFDRLLTL LGAREHIPAV
     GFSLWLDRIE RAIAAAGGA
//

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