(data stored in ACNUC7421 zone)

SWISSPROT: NCPP_SULIK

ID   NCPP_SULIK              Reviewed;         176 AA.
AC   C4KJG4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   RecName: Full=Probable non-canonical purine NTP phosphatase {ECO:0000255|HAMAP-Rule:MF_00648};
DE            EC=3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00648};
GN   OrderedLocusNames=M164_0048;
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3;
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- FUNCTION: Phosphatase that hydrolyzes non-canonical purine
CC       nucleotides such as XTP and ITP to their respective diphosphate
CC       derivatives. Probably excludes non-canonical purines from DNA
CC       precursor pool, thus preventing their incorporation into DNA and
CC       avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_00648}.
CC   -!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a
CC       nucleoside diphosphate + monophosphate. {ECO:0000255|HAMAP-
CC       Rule:MF_00648}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00648};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00648};
CC       Note=Binds 1 divalent metal cation per subunit; can use either
CC       Mg(2+) or Mn(2+). {ECO:0000255|HAMAP-Rule:MF_00648};
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00648}.
CC   -!- SIMILARITY: Belongs to the YjjX NTPase family. {ECO:0000255|HAMAP-
CC       Rule:MF_00648}.
DR   EMBL; CP001402; ACR40684.1; -; Genomic_DNA.
DR   RefSeq; WP_012718325.1; NC_012726.1.
DR   ProteinModelPortal; C4KJG4; -.
DR   SMR; C4KJG4; -.
DR   EnsemblBacteria; ACR40684; ACR40684; M164_0048.
DR   GeneID; 7812108; -.
DR   KEGG; sid:M164_0048; -.
DR   HOGENOM; HOG000098032; -.
DR   OMA; MALIPRM; -.
DR   OrthoDB; POG093Z0CDS; -.
DR   BioCyc; SISL426118:GI01-48-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.950.10; -; 1.
DR   HAMAP; MF_00648; Non_canon_purine_NTPase_YjjX; 1.
DR   InterPro; IPR029001; ITPase-like_fam.
DR   InterPro; IPR002786; Non_canon_purine_NTPase.
DR   InterPro; IPR026533; NTPase/PRRC1.
DR   Pfam; PF01931; NTPase_I-T; 1.
DR   SUPFAM; SSF52972; SSF52972; 1.
PE   3: Inferred from homology;
DR   PRODOM; C4KJG4.
DR   SWISS-2DPAGE; C4KJG4.
KW   Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding;
KW   Nucleotide metabolism; Nucleotide-binding.
FT   CHAIN         1    176       Probable non-canonical purine NTP
FT                                phosphatase.
FT                                /FTId=PRO_1000212392.
FT   METAL        36     36       Manganese or magnesium.
FT                                {ECO:0000255|HAMAP-Rule:MF_00648}.
SQ   SEQUENCE   176 AA;  19142 MW;  14F73BC2E0ABA71F CRC64;
     MVTIALGSRN PVKINATKEA LDVLKLNWDL IGIEVDSGVD KQPFCDQTYV GARNRALNVI
     RVTNADIGLG IEGGVCNVYG KFIANAVVYV ITKEGLENFA ISSSFTLPSS MVSLILQGKE
     LGEASDIIFK TNNSKTKEGA IGLLTNNVIN RKMLYVQPIV LALYPIYNTM INNTPF
//

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