(data stored in ACNUC7421 zone)

SWISSPROT: C4KKB3_SULIK

ID   C4KKB3_SULIK            Unreviewed;       209 AA.
AC   C4KKB3;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 41.
DE   RecName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase {ECO:0000256|HAMAP-Rule:MF_02131};
DE            Short=HPPK {ECO:0000256|HAMAP-Rule:MF_02131};
DE            EC=2.7.6.3 {ECO:0000256|HAMAP-Rule:MF_02131};
DE   AltName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase {ECO:0000256|HAMAP-Rule:MF_02131};
DE   AltName: Full=6-hydroxymethyl-7,8-dihydropterin diphosphokinase {ECO:0000256|HAMAP-Rule:MF_02131};
DE            Short=6-HMPDK {ECO:0000256|HAMAP-Rule:MF_02131};
DE   AltName: Full=7,8-dihydro-6-hydroxymethylpterin diphosphokinase {ECO:0000256|HAMAP-Rule:MF_02131};
DE   AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase {ECO:0000256|HAMAP-Rule:MF_02131};
DE            Short=PPPK {ECO:0000256|HAMAP-Rule:MF_02131};
GN   Name=mptE {ECO:0000256|HAMAP-Rule:MF_02131};
GN   OrderedLocusNames=M164_0220 {ECO:0000313|EMBL:ACR40854.1};
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118 {ECO:0000313|EMBL:ACR40854.1, ECO:0000313|Proteomes:UP000001479};
RN   [1] {ECO:0000313|EMBL:ACR40854.1, ECO:0000313|Proteomes:UP000001479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3 {ECO:0000313|Proteomes:UP000001479};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- FUNCTION: Catalyzes the transfer of diphosphate from ATP to 6-
CC       hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-
CC       hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).
CC       {ECO:0000256|HAMAP-Rule:MF_02131}.
CC   -!- CATALYTIC ACTIVITY: ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP
CC       + 6-hydroxymethyl-7,8-dihydropterin diphosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_02131}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02131};
CC   -!- SIMILARITY: Belongs to the archaeal 6-HMPDK family.
CC       {ECO:0000256|HAMAP-Rule:MF_02131}.
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DR   EMBL; CP001402; ACR40854.1; -; Genomic_DNA.
DR   EnsemblBacteria; ACR40854; ACR40854; M164_0220.
DR   KEGG; sid:M164_0220; -.
DR   HOGENOM; HOG000226046; -.
DR   KO; K07142; -.
DR   OMA; DGDRCCF; -.
DR   OrthoDB; POG093Z0FS0; -.
DR   BioCyc; SISL426118:GI01-222-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:InterPro.
DR   GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_02131; HMPDK_arch; 1.
DR   InterPro; IPR027510; HMPDK_MptE.
DR   InterPro; IPR002826; MptE-like.
DR   InterPro; IPR007371; TPK_catalytic.
DR   Pfam; PF01973; MAF_flag10; 1.
DR   SUPFAM; SSF63999; SSF63999; 1.
PE   3: Inferred from homology;
DR   PRODOM; C4KKB3.
DR   SWISS-2DPAGE; C4KKB3.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_02131};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001479};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_02131};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_02131};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_02131};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_02131}.
SQ   SEQUENCE   209 AA;  23877 MW;  3F2EAEFAD0F99AB7 CRC64;
     MNFYKIVRSW FGFKERDDYI SASILNYLVT KEYDESELRD IIKGREIAVV GASPQLDKIN
     KIEEDVIIAA DGATNYLINI GVIPDIVVTD LDGLQTFHKN PIYLVLAHGD NISLLPKVKE
     MDKVIPNSQV MPFGRLRLYG GFTDGDRAVV LAKYMGARKI RLYAMDFESG IIGKYSKPYY
     KRDVPASMIK RKKLEIARMI IEQVLNYDE
//

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