(data stored in ACNUC7421 zone)

SWISSPROT: LEUD_SULIK

ID   LEUD_SULIK              Reviewed;         165 AA.
AC   C4KKU5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 49.
DE   RecName: Full=3-isopropylmalate dehydratase small subunit {ECO:0000255|HAMAP-Rule:MF_01032};
DE            EC=4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01032};
DE   AltName: Full=Alpha-IPM isomerase {ECO:0000255|HAMAP-Rule:MF_01032};
DE            Short=IPMI {ECO:0000255|HAMAP-Rule:MF_01032};
DE   AltName: Full=Isopropylmalate isomerase {ECO:0000255|HAMAP-Rule:MF_01032};
GN   Name=leuD {ECO:0000255|HAMAP-Rule:MF_01032};
GN   OrderedLocusNames=M164_0276;
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3;
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate
CC       and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
CC       {ECO:0000255|HAMAP-Rule:MF_01032}.
CC   -!- CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-
CC       isopropylmalate. {ECO:0000255|HAMAP-Rule:MF_01032}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-
CC       leucine from 3-methyl-2-oxobutanoate: step 2/4.
CC       {ECO:0000255|HAMAP-Rule:MF_01032}.
CC   -!- SUBUNIT: Heterodimer of LeuC and LeuD. {ECO:0000255|HAMAP-
CC       Rule:MF_01032}.
CC   -!- SIMILARITY: Belongs to the LeuD family. LeuD type 2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01032}.
DR   EMBL; CP001402; ACR40910.1; -; Genomic_DNA.
DR   RefSeq; WP_012710429.1; NC_012726.1.
DR   SMR; C4KKU5; -.
DR   EnsemblBacteria; ACR40910; ACR40910; M164_0276.
DR   GeneID; 7794282; -.
DR   KEGG; sid:M164_0276; -.
DR   HOGENOM; HOG000222940; -.
DR   KO; K01704; -.
DR   OMA; GLPIIEC; -.
DR   OrthoDB; POG093Z0CU3; -.
DR   BioCyc; SISL426118:GI01-278-MONOMER; -.
DR   UniPathway; UPA00048; UER00071.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd01577; IPMI_Swivel; 1.
DR   Gene3D; 3.20.19.10; -; 1.
DR   HAMAP; MF_01032; LeuD_type2; 1.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   InterPro; IPR033940; IPMI_Swivel.
DR   InterPro; IPR011827; LeuD_type2/HacB/DmdB.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR02087; LEUD_arch; 1.
PE   3: Inferred from homology;
DR   PRODOM; C4KKU5.
DR   SWISS-2DPAGE; C4KKU5.
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Leucine biosynthesis; Lyase.
FT   CHAIN         1    165       3-isopropylmalate dehydratase small
FT                                subunit.
FT                                /FTId=PRO_1000213369.
SQ   SEQUENCE   165 AA;  18018 MW;  69D22CC3B61042FB CRC64;
     MIIEGPVIKF GDKIDTDIII PARYLKYTDP QYLAQHAMEP LDPEFYKKAS KGVIIVAGKV
     FGMGSSREQA AIALKAAGVK AVVAESFARI FYRNAINNGL PVITLPNSTK EIDENSYVKI
     DVETGEILVG NKVLKGKGIT GMALEILQAG GIMEYLKKMQ TVNRN
//

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