(data stored in ACNUC7421 zone)

SWISSPROT: SYT_SULIK

ID   SYT_SULIK               Reviewed;         545 AA.
AC   C4KKV9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 45.
DE   RecName: Full=Threonine--tRNA ligase {ECO:0000255|HAMAP-Rule:MF_00184};
DE            EC=6.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00184};
DE   AltName: Full=Threonyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_00184};
DE            Short=ThrRS {ECO:0000255|HAMAP-Rule:MF_00184};
GN   Name=thrS {ECO:0000255|HAMAP-Rule:MF_00184};
GN   OrderedLocusNames=M164_0290;
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3;
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- CATALYTIC ACTIVITY: ATP + L-threonine + tRNA(Thr) = AMP +
CC       diphosphate + L-threonyl-tRNA(Thr). {ECO:0000255|HAMAP-
CC       Rule:MF_00184}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00184};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_00184};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00184}.
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. {ECO:0000255|HAMAP-Rule:MF_00184}.
DR   EMBL; CP001402; ACR40924.1; -; Genomic_DNA.
DR   RefSeq; WP_012735443.1; NC_012726.1.
DR   SMR; C4KKV9; -.
DR   EnsemblBacteria; ACR40924; ACR40924; M164_0290.
DR   KEGG; sid:M164_0290; -.
DR   HOGENOM; HOG000003878; -.
DR   KO; K01868; -.
DR   OMA; FYYDFAY; -.
DR   OrthoDB; POG093Z01GO; -.
DR   BioCyc; SISL426118:GI01-292-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004829; F:threonine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006435; P:threonyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00771; ThrRS_core; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   HAMAP; MF_00184; Thr_tRNA_synth; 1.
DR   InterPro; IPR002314; aa-tRNA-synt_IIb.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR004154; Anticodon-bd.
DR   InterPro; IPR002320; Thr-tRNA-ligase_IIa.
DR   InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR   InterPro; IPR033728; ThrRS_core.
DR   PANTHER; PTHR11451; PTHR11451; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF00587; tRNA-synt_2b; 1.
DR   PRINTS; PR01047; TRNASYNTHTHR.
DR   SUPFAM; SSF52954; SSF52954; 1.
DR   SUPFAM; SSF55186; SSF55186; 1.
DR   TIGRFAMs; TIGR00418; thrS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
DR   PRODOM; C4KKV9.
DR   SWISS-2DPAGE; C4KKV9.
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Metal-binding; Nucleotide-binding; Protein biosynthesis; Zinc.
FT   CHAIN         1    545       Threonine--tRNA ligase.
FT                                /FTId=PRO_1000203921.
FT   REGION      139    433       Catalytic.
FT   METAL       231    231       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00184}.
FT   METAL       282    282       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00184}.
FT   METAL       410    410       Zinc; catalytic. {ECO:0000255|HAMAP-
FT                                Rule:MF_00184}.
SQ   SEQUENCE   545 AA;  63230 MW;  C0575A49885DA2CA CRC64;
     MESYKPVWLK GAVILAINLI DKGYKPVAVG LGERDFYIDV KSDTSITLDE VKKAINENVL
     ANVPIENNQI VYKGNKVSII EDKVSISTNL NPKYFEILNI STHHPNPNEQ YVRIRGVAFE
     TEEQLKDYLT WLEKAEETDH RLIGEKLDLF SFHEEAGSGL VLFHPKGQTI RNELIAFMRE
     INDSMGYQEV YTSHVFKTDI WKISGHYTLY RDKLIVFNME GDEYGVKPMN CPAHILIYKS
     KPRTYRDLPI RFSEFGHVYR WEKKGELYGL LRVRGFVQDD GHIFLREDQL MEEIKMLISK
     TVEVWHKFGF KDDDIKPYLS TRPDESIGSD ELWEKATNAL ISALQESGLK FGIKEKEGAF
     YGPKIDFEIR DSLGRWWQLS TIQVDFNLPE RFKLEYIDKD GIKKRPVMVH RAIYGSIDRF
     VAILLEHFKG KLPTWLSSVQ VRVLPITDEV NEYAEKVLND MRKRRIRAEI DYAGETLSKR
     IKNAYDQGVP YILIVGKKEA SEGTVTVRAR GNIEVRNVKF EKFLELLITE IAQRDVEQTT
     VKALK
//

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