(data stored in ACNUC7421 zone)

SWISSPROT: C4KDT3_SULIK

ID   C4KDT3_SULIK            Unreviewed;       557 AA.
AC   C4KDT3;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 44.
DE   SubName: Full=Thiamine pyrophosphate protein central region {ECO:0000313|EMBL:ACR41056.1};
GN   OrderedLocusNames=M164_0426 {ECO:0000313|EMBL:ACR41056.1};
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118 {ECO:0000313|EMBL:ACR41056.1, ECO:0000313|Proteomes:UP000001479};
RN   [1] {ECO:0000313|EMBL:ACR41056.1, ECO:0000313|Proteomes:UP000001479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3 {ECO:0000313|Proteomes:UP000001479};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP001402; ACR41056.1; -; Genomic_DNA.
DR   RefSeq; WP_012735516.1; NC_012726.1.
DR   ProteinModelPortal; C4KDT3; -.
DR   EnsemblBacteria; ACR41056; ACR41056; M164_0426.
DR   KEGG; sid:M164_0426; -.
DR   HOGENOM; HOG000258446; -.
DR   KO; K01652; -.
DR   OMA; GFPIKPQ; -.
DR   OrthoDB; POG093Z01J9; -.
DR   BioCyc; SISL426118:GI01-431-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1220; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
DR   PRODOM; C4KDT3.
DR   SWISS-2DPAGE; C4KDT3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001479};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        9    173       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      200    335       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      393    537       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   557 AA;  61406 MW;  4A479EAC53C3DEA2 CRC64;
     MRVKSLIFMN GSKLLLTLLK DYDVKHIFGL PGESSISLYD QLKEGEVLHI ITRDERNAVY
     MADTYAKLTY KPGVVEGPSV GSIYMLPGVA EAYKSSTPLI VITTDTPLYG EKENYLTALD
     QASLFRPITK ETITVYNVEE LPHAIRRAFR LSTSGKPGPV HIRILLDVLE DELKGNVELK
     AQKEFSKYPS QRPLADREMI RKAVDLILKS EFPVIICGQG ALYSMAWDEV TELAELLGIL
     VGTTITGKGC IPETHPLSIG VVGGRGGANF SNSIVDKSDL VILIGSNTDS ANTYNWTIPS
     RGKTVIHIDI SETETGNNYD SINLIGDAKV TLRELIKEIK GSGKIDKKNI ILDRSAFEDR
     LSKERREAVN PLRFIKELWS LSPEEAVLIA DPGVSAIYTA AFYKAKKVGR YFIFNYGLGG
     LGYSIPASVG AYFARPNSLI FSLSGDGSFG FSAGELETIR RVNANVVIII FNNGSYGWIR
     AEMKARGKDI VGTDFSSPDY VKIAEGYGLS AYGITNDEEI SDTLKRAIKN TPSLVEVIVE
     PEDKFVPPVM PWSKRFL
//

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