(data stored in ACNUC7421 zone)

SWISSPROT: C4KF70_SULIK

ID   C4KF70_SULIK            Unreviewed;       404 AA.
AC   C4KF70;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 46.
DE   SubName: Full=Nucleotide sugar dehydrogenase {ECO:0000313|EMBL:ACR41286.1};
DE            EC=1.1.1.22 {ECO:0000313|EMBL:ACR41286.1};
GN   OrderedLocusNames=M164_0668 {ECO:0000313|EMBL:ACR41286.1};
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118 {ECO:0000313|EMBL:ACR41286.1, ECO:0000313|Proteomes:UP000001479};
RN   [1] {ECO:0000313|EMBL:ACR41286.1, ECO:0000313|Proteomes:UP000001479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3 {ECO:0000313|Proteomes:UP000001479};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CP001402; ACR41286.1; -; Genomic_DNA.
DR   RefSeq; WP_012735643.1; NC_012726.1.
DR   ProteinModelPortal; C4KF70; -.
DR   EnsemblBacteria; ACR41286; ACR41286; M164_0668.
DR   KEGG; sid:M164_0668; -.
DR   HOGENOM; HOG000153773; -.
DR   KO; K00012; -.
DR   OMA; LCTEWDE; -.
DR   OrthoDB; POG093Z033N; -.
DR   BioCyc; SISL426118:GI01-683-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
DR   PRODOM; C4KF70.
DR   SWISS-2DPAGE; C4KF70.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001479};
KW   NAD {ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ACR41286.1}.
FT   DOMAIN      302    390       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    249    249       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      83     83       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     117    117       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     143    143       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     252    252       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     316    316       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   404 AA;  44689 MW;  DA48D6DDC45F4510 CRC64;
     MIIGIVGLGY VGLVTGAALA DQGHYVIGVD IDEKKVNGLN CNRIPIYEPG LDELIMKNKK
     KIQFTTNYSD LSDADIVFIA VSTPTINGKI FLDYIYSAGE NLQKILNKES VIVIKSTVVP
     GTSRKVKEIT KREVIVNPEF LREGSAIIDT KHPERIVIGG DDEKAIKLIE DLWSFTNSPI
     IKTSMEEAEL IKYAANSFLA VKISFINEIA NLCEKIPNCD INNIAKAIGM DKRISPYFLN
     AGLGFGGSCF PKDTLAITSF AKDLGERLHI VEAAIEVNNE RPFRAVKMME DLIGKLENKS
     ICILGIAFKP NTDDTRESVG LKIAKLIREK GGKVIVYDPK AKADLEMVSL DECINKADGI
     IIATEWDEFR GLEDRLKGKY VVDGRRILNY KKLVKGRFKA IGVS
//

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