(data stored in ACNUC7421 zone)

SWISSPROT: C4KFA0_SULIK

ID   C4KFA0_SULIK            Unreviewed;       612 AA.
AC   C4KFA0;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   07-JUN-2017, entry version 57.
DE   RecName: Full=Indolepyruvate oxidoreductase subunit IorA {ECO:0000256|PIRNR:PIRNR006439};
DE            Short=IOR {ECO:0000256|PIRNR:PIRNR006439};
DE            EC=1.2.7.8 {ECO:0000256|PIRNR:PIRNR006439};
DE   AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit alpha {ECO:0000256|PIRNR:PIRNR006439};
GN   OrderedLocusNames=M164_0699 {ECO:0000313|EMBL:ACR41316.1};
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118 {ECO:0000313|EMBL:ACR41316.1, ECO:0000313|Proteomes:UP000001479};
RN   [1] {ECO:0000313|EMBL:ACR41316.1, ECO:0000313|Proteomes:UP000001479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3 {ECO:0000313|Proteomes:UP000001479};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative
CC       decarboxylation of arylpyruvates. {ECO:0000256|PIRNR:PIRNR006439}.
CC   -!- CATALYTIC ACTIVITY: (Indol-3-yl)pyruvate + CoA + 2 oxidized
CC       ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+). {ECO:0000256|PIRNR:PIRNR006439}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006439,
CC         ECO:0000256|PIRSR:PIRSR006439-50};
CC       Note=Binds 2 [4Fe-4S] clusters. In this family the first cluster
CC       has a non-standard and varying [4Fe-4S] binding motif
CC       CX(2)CX(2)CX(4-5)CP. {ECO:0000256|PIRNR:PIRNR006439,
CC       ECO:0000256|PIRSR:PIRSR006439-50};
CC   -!- SUBUNIT: Heterodimer of the IorA and IorB subunits.
CC       {ECO:0000256|PIRNR:PIRNR006439}.
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DR   EMBL; CP001402; ACR41316.1; -; Genomic_DNA.
DR   RefSeq; WP_012735663.1; NC_012726.1.
DR   ProteinModelPortal; C4KFA0; -.
DR   EnsemblBacteria; ACR41316; ACR41316; M164_0699.
DR   KEGG; sid:M164_0699; -.
DR   HOGENOM; HOG000224871; -.
DR   KO; K00179; -.
DR   OMA; IGDSTFM; -.
DR   OrthoDB; POG093Z00SP; -.
DR   BioCyc; SISL426118:GI01-715-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017721; Indolepyruvate_Fd_OxRdtase_asu.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   PIRSF; PIRSF006439; Indolepyruvate_ferr_oxidored; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   SUPFAM; SSF52922; SSF52922; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   4: Predicted;
DR   PRODOM; C4KFA0.
DR   SWISS-2DPAGE; C4KFA0.
KW   4Fe-4S {ECO:0000256|PIRNR:PIRNR006439, ECO:0000256|PIRSR:PIRSR006439-
KW   50}; Complete proteome {ECO:0000313|Proteomes:UP000001479};
KW   Electron transport {ECO:0000256|PIRNR:PIRNR006439};
KW   Iron {ECO:0000256|PIRNR:PIRNR006439, ECO:0000256|PIRSR:PIRSR006439-
KW   50};
KW   Iron-sulfur {ECO:0000256|PIRNR:PIRNR006439,
KW   ECO:0000256|PIRSR:PIRSR006439-50};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR006439,
KW   ECO:0000256|PIRSR:PIRSR006439-50};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR006439};
KW   Transport {ECO:0000256|PIRNR:PIRNR006439}.
FT   DOMAIN      542    571       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
FT   DOMAIN      572    601       4Fe-4S ferredoxin-type.
FT                                {ECO:0000259|PROSITE:PS51379}.
FT   METAL       551    551       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       554    554       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       557    557       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       563    563       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       581    581       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       584    584       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       587    587       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
FT   METAL       591    591       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000256|PIRSR:PIRSR006439-50}.
SQ   SEQUENCE   612 AA;  67073 MW;  C7DCAD3CDEC7B337 CRC64;
     MIELSTTKRV ILGNEAIAFG ALSAGVSIAA GYPGTPSTEI IETLMAYGKI YTEWSANEKV
     AFETAYGAAI NGAFALTTMK HVGLNVAADP LMSSSYTGVE GALVIVSADD PSMWSSQNEQ
     DNRYYGLHAL IPVIEPYDPQ SAHDLTIEAF KLSNKVKHPV ILRSTTRIGH IRGPVELKPP
     SRPILGKLIK DPKRYVLVPE NARRNRVEQL KRWEKIEEEV EGLNGLIDND SENLIIASGI
     SFGYVIDAMK ELDIKANVLR LSTPVPIPKR LFLKAVSNSK RVLIVEEGEP IVEYQIKDLL
     YDQGIRVELH GKDLVSRVGE MTLDKVYYAF SKFFGLDLVT EYLEVPQDIP PRPPALCPGC
     PHRSSFTDLK KAITMASFKP NETFISGDIG CYTLGLLPPF DTQDSSTDMG SSIGIANGVY
     RATGNIPIAV IGDSTFFHSG ISALANAVYT QTPMLVLVLD NRSTAMTGQQ PSPSKEIDIG
     EVAKGLGVKY VKYVDPFDVN SSIKELSNAL KWVRENKQPA VVIAKRACAL LVMDNVEENN
     LPKAIVDLEK CTGCSICYDY FTCPAIIPRK DKKAEIDNYT CIGCGACIPV CPFKAISLKG
     NKPEKWDELW LG
//

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