(data stored in ACNUC7421 zone)

SWISSPROT: C5BBB5_EDWI9

ID   C5BBB5_EDWI9            Unreviewed;       362 AA.
AC   C5BBB5;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase {ECO:0000256|HAMAP-Rule:MF_02030};
DE            EC=2.7.8.33 {ECO:0000256|HAMAP-Rule:MF_02030};
DE   AltName: Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase {ECO:0000256|HAMAP-Rule:MF_02030};
DE   AltName: Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase {ECO:0000256|HAMAP-Rule:MF_02030};
GN   Name=wecA {ECO:0000256|HAMAP-Rule:MF_02030};
GN   OrderedLocusNames=NT01EI_0090 {ECO:0000313|EMBL:ACR67350.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67350.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR67350.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR67350.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated
RT   with a Natural Channel Catfish Outbreak of Enteric Septicemia of
RT   Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- FUNCTION: Catalyzes the transfer of the GlcNAc-1-phosphate moiety
CC       from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate
CC       (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-
CC       C55). {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-
CC         alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-
CC         di-trans,octa-cis-undecaprenol + UMP; Xref=Rhea:RHEA:28090,
CC         ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392,
CC         ChEBI:CHEBI:62959; EC=2.7.8.33; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02030};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02030};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02030};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial
CC       common antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02030}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02030}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02030}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 4 family. WecA
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_02030}.
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DR   EMBL; CP001600; ACR67350.1; -; Genomic_DNA.
DR   RefSeq; WP_015869569.1; NC_012779.2.
DR   EnsemblBacteria; ACR67350; ACR67350; NT01EI_0090.
DR   GeneID; 7959809; -.
DR   KEGG; eic:NT01EI_0090; -.
DR   PATRIC; fig|634503.3.peg.84; -.
DR   eggNOG; ENOG4105ESV; Bacteria.
DR   eggNOG; COG0472; LUCA.
DR   HOGENOM; HOG000275125; -.
DR   KO; K02851; -.
DR   OMA; QKATMPD; -.
DR   OrthoDB; 728505at2; -.
DR   BioCyc; EICT634503:G1GVC-83-MONOMER; -.
DR   UniPathway; UPA00281; -.
DR   UniPathway; UPA00566; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0008963; F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IEA:InterPro.
DR   GO; GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
DR   GO; GO:0036380; F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009243; P:O antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02030; WecA_Gammaproteo; 1.
DR   InterPro; IPR012750; ECA_WecA-rel.
DR   InterPro; IPR000715; Glycosyl_transferase_4.
DR   PANTHER; PTHR22926; PTHR22926; 1.
DR   Pfam; PF00953; Glycos_transf_4; 1.
DR   TIGRFAMs; TIGR02380; ECA_wecA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BBB5.
DR   SWISS-2DPAGE; C5BBB5.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_02030,
KW   ECO:0000313|EMBL:ACR67350.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_02030};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_02030}.
FT   TRANSMEM      6     24       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM     45     66       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM     72     89       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    101    119       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    131    149       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    161    179       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    185    206       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    213    232       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    244    263       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    294    316       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
FT   TRANSMEM    322    340       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_02030}.
SQ   SEQUENCE   362 AA;  40266 MW;  E39A3E6FE60B4542 CRC64;
     MNLLTLSSKF FLIFLFSMAF LLVARRVAKK IGLVDKPNYR KRHQGLIPLV GGISVYAGIC
     FTFLFFKPYI PHATLYLICA GILVLVGALD DRFDISVKFR ATVQALIAIA MMVAGGLYLR
     SLGFVLGPWE LILGPFGYLV TLFAVWAAIN AFNMVDGIDG LLGGLSCVTF AAMGILLQWD
     GQPDLALWCF AIIAATLPYI LLNLGVVGPR FKVFMGDAGS TLIGFTVIWI LLESTQGRGH
     PMNPVTALWV IAIPLMDMIA IMYRRLRKGM SPFSPDRQHI HHLIMRAGFT SRQAFVLITL
     AAVLLAAIGV LGEIWLPEYA MMALFLLAFA LYGYCIKRAW RVARMVKRFK RRLRRKSTGI
     HV
//

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