(data stored in ACNUC7421 zone)

SWISSPROT: C5BBB9_EDWI9

ID   C5BBB9_EDWI9            Unreviewed;       354 AA.
AC   C5BBB9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 2.
DT   07-JUN-2017, entry version 58.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   OrderedLocusNames=NT01EI_0094 {ECO:0000313|EMBL:ACR67354.2};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR67354.2, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-
CC       alpha-D-glucose + H(2)O. {ECO:0000256|RuleBase:RU004473}.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|RuleBase:RU004473}.
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DR   EMBL; CP001600; ACR67354.2; -; Genomic_DNA.
DR   ProteinModelPortal; C5BBB9; -.
DR   STRING; 634503.NT01EI_0094; -.
DR   EnsemblBacteria; ACR67354; ACR67354; NT01EI_0094.
DR   KEGG; eic:NT01EI_0094; -.
DR   eggNOG; ENOG4105C1B; Bacteria.
DR   eggNOG; COG1088; LUCA.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OrthoDB; POG091H044P; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5BBB9.
DR   SWISS-2DPAGE; C5BBB9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001485};
KW   Lyase {ECO:0000256|RuleBase:RU004473, ECO:0000313|EMBL:ACR67354.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001485}.
FT   DOMAIN        5    327       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   354 AA;  39465 MW;  40D0E232071C21E8 CRC64;
     MRRILVTGGA GFIGSAVVRH IIMDTTDSVV VVDKLTYAGN LASLAPVADS DRYAFERADI
     GDRAAMDRIL AQYRPDAIMH LAAESHVDRS IDGPADFIQT NIVGTYTLLE ATRGYWSALP
     VALRAAFRFH HISTDEVYGD LHDPQALFRE DTPYAPSSPY STSKAASDHL VRAWLRTYGL
     PTLITNCSNN YGPYHFPEKL IPLTIINALA AKPLPVYGNG LQVRDWLYVE DHACALYRVL
     TTGQVGETYN IGGHNERRNI DVVTTLCALL QEMVPEKPVG VRHFADLITY VADRPGHDVR
     YAIDAAKIER ELGWRPQETF ESGIRKTVAW YLANERWWRA VMDGSYAGER LGLA
//

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